Pieris Announces Positive Preclinical Data on c-Met Anticalin Drug Program
“These preclinical data firmly support our conviction that an Anticalin, which is monomeric by nature, is particularly suited for antagonizing a receptor activated through dimerization such as c-Met,” stated Stephen Yoder, CEO of Pieris. “Based on the strength of these data, we have initiated additional studies in multiple models to further validate this exciting compound.”
Produced in a tumor xenograft mouse model of cancer autocrine for the production of human HGF ligand, the data show potent dose-dependant inhibition of tumor growth by PRS-110 as compared to the untreated animals. PRS-110 targets c-Met, or mesenchymal-epithelial transition factor, which is a receptor often activated on cancer cells, and plays a role in cancer cell proliferation, metastasis and angiogenesis.
Pieris has developed its anti-c-Met PRS-110 compound using its proprietary Anticalin technology. Anticalins are engineered lipocalins, endogenous low-molecular weight human proteins typically found in blood plasma and other body fluids that naturally bind, store and transport a wide spectrum of molecules. Through its proprietary libraries, the company can rapidly generate Anticalins against a broad spectrum of therapeutic targets.
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