CORAT Therapeutics obtained regulatory authorization for clinical phase Ib/II trial with the SARS-CoV-2 neutralizing human antibody COR-101
COR-101 is a human antibody that blocks virus infection by binding to the spike protein
CORAT Therapeutics GmbH
"We are very happy to have reached this crucial step in COR-101 development. Many thanks to the support of the State of Lower Saxony and our private investors", comments Dr. Andreas Herrmann, CEO of CORAT Therapeutics, and continues: "We feel confident that COR-101 can fill the gap in the medical need for the treatment of hospitalized COVID-19 patients that have moderate and severe symptoms, where no other specific treatment is available at this time worldwide. The development of specific therapeutics to treat COVID-19 diseases is next to vaccination and testing an important pillar to effectively fight the pandemic." The study (ClinicalTrials.gov ID: NCT04674566) is a randomized, double-blind, placebo-controlled, parallelgroup, first-in-human, phase Ib/II study to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity, and efficacy of COR-101 in hospitalized patients with moderate to severe COVID-19. The study will start in six study centers in Germany and expanded up to 15 study centers in Europe to give fast access to the patients. The overall medical responsibility for the study lies with Prof. Dr. Helmut Salih at the University Hospital in Tuebingen.
COR-101 was developed in close cooperation with the University of Technology in Braunschweig (TUBS) and the human antibody development company YUMAB GmbH. Dr. Thomas Schirrmann, COO of CORAT Therapeutics, who led the preclinical development, commented: "We are convinced that neutralizing antibodies like COR-101 add an urgently needed treatment option for all the patients, who cannot be vaccinated due to other conditions, or all those who do not develop a sufficient immune response after vaccinations. Antibodies are known as very robust, safe, and easy-to-manufacture medications against infections for more than hundred years, and they can close the treatment gap that the current vaccines cannot fill. We are confidently looking forward to obtain a drug that will help patients to recover from COVID-19 and that saves lives."
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Topic world Antibodies
Antibodies are specialized molecules of our immune system that can specifically recognize and neutralize pathogens or foreign substances. Antibody research in biotech and pharma has recognized this natural defense potential and is working intensively to make it therapeutically useful. From monoclonal antibodies used against cancer or autoimmune diseases to antibody-drug conjugates that specifically transport drugs to disease cells - the possibilities are enormous
Topic world Antibodies
Antibodies are specialized molecules of our immune system that can specifically recognize and neutralize pathogens or foreign substances. Antibody research in biotech and pharma has recognized this natural defense potential and is working intensively to make it therapeutically useful. From monoclonal antibodies used against cancer or autoimmune diseases to antibody-drug conjugates that specifically transport drugs to disease cells - the possibilities are enormous