Novel mechanism for persistence in staphylococcal chronic infections
© Nora Dinhopl
Staphylococci are common bacteria of the human and animal skin. A problematic species is S. aureus, which can be harmful for humans, but can also be a major cause of infections of the udder in dairy cows (bovine mastitis). Frequent consequences are long-lasting and recurrent infections during which the bacteria constantly refine its properties and adapt to the host.
In a recent study at the Vetmeduni Vienna, funded by the Austrian Science Fund (FWF), an international team of researchers led by Tom Grunert investigated the adaptation of S. aureus within the host animal over the course of three months in a naturally infected dairy cow with chronic, subclinical mastitis. The analysis of the bacterial genomes revealed a complete replacement of the original bacterial strain by another genetic variant – caused by an adaptation through mutation and selection.
Bacterial in-host evolution opens a new, alternative route to persistence
This study was the first to observe a genetic and phenotypical adaptation of S. aureus within its bovine host. Helene Marbach from the Unit of Functional Microbiology at Vetmeduni Vienna: “The mutation in the bacterial genome involves in particular only a single base exchange in a gene. The newly evolved clone exhibits strong changes in infection-relevant phenotypes, such as higher proteolytic activity and biofilm formation.” The researchers were thus able to demonstrate a new, alternative mechanism for persistence of S. aureus leading away from intracellular towards extracellular persistence.
Original publication
"Within-host evolution of bovine Staphylococcus aureus selects for a SigB-deficient pathotype characterized by reduced virulence but enhanced proteolytic activity and biofilm formation"; Helene Marbach, Katharina Mayer, Claus Vogl, Jean Y. H. Lee, Ian R. Monk, Daniel O. Sordelli, Fernanda R. Buzzola, Monika Ehling-Schulz and Tom Grunert; Scientific Reports; 2019
Most read news
Original publication
"Within-host evolution of bovine Staphylococcus aureus selects for a SigB-deficient pathotype characterized by reduced virulence but enhanced proteolytic activity and biofilm formation"; Helene Marbach, Katharina Mayer, Claus Vogl, Jean Y. H. Lee, Ian R. Monk, Daniel O. Sordelli, Fernanda R. Buzzola, Monika Ehling-Schulz and Tom Grunert; Scientific Reports; 2019
Other news from the department science
Get the life science industry in your inbox
From now on, don't miss a thing: Our newsletter for biotechnology, pharma and life sciences brings you up to date every Tuesday and Thursday. The latest industry news, product highlights and innovations - compact and easy to understand in your inbox. Researched by us so you don't have to.