Let there be light: Synthesizing organic compounds
Yokohama National University
A team from Yokohama National University in Japan has taken a step toward making this wish a reality with their latest study, published on July 19 in the Journal of Organic Chemistry.
The researchers developed oxygen heterocycles, which are ring structures consisting of atoms from two or more elements. These compounds make up all of the nucleic acids in a person's genetic code. Another version of heterocycles, containing nitrogen, are in more than half of the pharmaceuticals produced in the United States. Oxygen heterocycles in particular contain at least one oxygen atom. They have a variety of uses, including in medications to treat cancer and heart failure.
"We focused on oxygen heterocycles, which have attracted significant interest due to the relevance of their structural units in medicinal chemistry and materials science," said Yujiro Hoshino, the study's corresponding author and a research fellow in the Graduate School of Environment and Information Sciences at Yokohama National University.
Professor Kiyoshi Honda, another corresponding author of the study from the Graduate School of Environment and Information Sciences added that their "goal was to develop cost-effective and milder synthetic routes to create oxygen heterocycles."
Traditionally, oxygen heterocycles are made by applying high temperatures to two molecules. The process consumes time and energy, and doesn't produce a significant number of heterocycles. Honda and Hoshino's team focused on a method involving the design of photo-sensitive carbon-based salts. They added the salts to two types of compounds, which form a ring once they react, and irradiated the combination with green light.
"This reaction was particularly attractive because it can hold a high number of atoms and provides efficient access to various synthetically useful oxygen-containing heterocycles," Hoshino said. "This reaction can also be carried out in mild experimental conditions - room temperature and visible light."
The process produced a high yield of oxygen heterocycles. According to Hoshino, the successful reaction was due to a structure on the salts called an electron-donating group. Electrons are excited by green light, and the salts extract an electron from the compound to react with the other compound components.
Next, the researchers plan to turn to different colored light to drive different reactions. They're specifically interested in establishing a red-light reaction, which is more difficult, according to Hoshino. Red light is a longer wavelength and lower frequency than green light, meaning it's closer infrared light than visible light on the spectrum chart. Red-light reactions could drive a higher production of heterocycles, but it requires more accuracy and efficiency.
"Our next goal is to expand the scope of reaction," Hoshino said. "We envision the expansion of the use of various visible-light-driven reactions in the future, and we plan to continue contributing to it."