Zimmer BioTech expands development team
Spin-off of Neu-Ulm-based medical device producer develops drug to treat skin cancer
“We are particularly delighted to have secured two highly rated experts in Dr. Reinhold Gahlmann and Stuart Marcus – especially during this phase,” says Zimmer. Dr. Gahlmann has more than 25 years of experience in pharmaceutical development, during which time he has served as director for clinical research at proDERM GmbH, head of pharmaceutical development at Biofrontera Bioscience GmbH and global project leader at Bayer AG. Stuart Marcus, meanwhile, was chief medical officer at DUSA Pharmaceuticals, where he developed the first commercially available ALA product for photodynamic therapy. He had previously been responsible for the development of the first photodynamic system on the market during his tenure as group director at Lederle Laboratories.
Next stage: clinical trial
Following completion of the toxicology studies and the evaluation of the stability data of the stored production batches, clinical trials will be performed. These trials are divided into three phases and must be completed before a drug can obtain approval. In addition to phase I and phase IIb clinical trials, phase III and maximal usage trials are already planned for Alevin deep. Since consultations with international approval authorities are part of the formal requirements of these clinical trials, a decision regarding the exact scope of the trials will be made once scientific advice has been sought.
Funding provided by Zimmer and High-Tech Gründerfonds
Together with Bonn-based High-Tech Gründerfonds, Germany’s largest seed stage investor, a total of EUR 2 million has so far been invested in the Alevin deep drug developed by Zimmer BioTech. The next financing round for the implementation of the first clinical trials is expected to raise around EUR 2.5 million. Binding commitments have already been made for a significant chunk of this sum. Dr. Frank Hensel, Senior Investment Manager at HTGF: “The development of a new formulation of the 5-Aminolevulinic acid compound represents a significant improvement for photodynamic therapy. We are confident of putting together a larger consortium of investors for the continued development of Alevin deep.”
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