AFFiRiS: Encouraging results from phase I studies of two Alzheimer's candidate vaccines trigger milestone payment

22-Oct-2009 - Austria

AFFiRiS AG announced that the primary endpoints have been met for the Phase I clinical studies of its two Alzheimer's vaccines AD01 and AD02, which demonstrated favourable safety and tolerability profiles. These results trigger a 10 million EUR milestone payment from licensee GlaxoSmithKline Biologicals. All 48 patients treated in these studies were given four vaccinations which were well tolerated and no serious side effects associated with the vaccine candidates were observed.

The results demonstrate the potential value of the AFFITOME® technology, which forms the platform for both of these vaccines and could result in a generation of highly specific vaccines. While analysing the clinical outcome in detail the company, together with GSK Biologicals is progressing to the next development stage. AFFiRiS AG is also using AFFITOME® technology to develop vaccines for Parkinson's disease, atherosclerosis and four other indications.

In October 2008 AFFiRiS concluded a licensing agreement with GSK Biologicals on jointly developing the Alzheimer's vaccines AD01 and AD02. Comprising total payments of up to EUR 430 million upon successful commercialisation, and the progress that has now been achieved is a key milestone in the collaboration. As part of this agreement, GSK Biologicals has gained access to the AFFITOME® technology of AFFiRiS, in the field of Alzheimer vaccination. In other indications AFFiRiS retains the exclusive rights to this technology.

https://www.bionity.com/en/news/108339/affiris-encouraging-results-from-phase-i-studies-of-two-alzheimer-s-candidate-vaccines-trigger-milestone-payment.html