European Commission approves Samsca for Hyponatraemia
Results from the SALT-1 and SALT-2 (Study of Ascending Levels of Tolvaptan in Hyponatraemia -1 and -2 ) trial programme showed that once-daily oral tolvaptan was effective in increasing serum sodium concentrations in patients with SIADH.
Samsca is a novel molecule designed to be an orally available antagonist of the vasopressin V2 receptor, which plays a role in the kidney’s regulation of fluid excretion. Samsca is designed to promote aquaresis, the excretion of electrolyte-free water.
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