Nabriva Therapeutics Initiates Clinical Phase I Trial of Pleuromutilin Antibiotic BC-3781
BC-3781 is highly active against key gram-positive pathogens, including MRSA, and gram-negative pathogens associated with community-acquired pneumonia. Its novel mode of action ensures that BC-3781 overcomes resistance mechanisms affecting all approved classes of antibiotics. In addition it belongs to the first generation of pleuromutilins to combine availability of both oral and i.v. dosage forms.
Dr. David Chiswell, CEO of Nabriva Therapeutics said: “In 2009 Nabriva intends to generate key human data for our two lead pleuromutilin-based antibiotics, BC-3205 and BC-3781. The BC-3205 oral administration clinical trial is already underway and we are delighted now to be also commencing the trial for intravenously administered BC-3781. Of particular note is that this is the first time a pleuromutilin antibiotic has been administered via the intravenous route opening the possibility for pleuromutilin based step-down therapy.”
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