NOXXON Announces Initiation of First Clinical Trial with a Spiegelmer
"With the initiation of this Phase I study, Spiegelmers® have reached the next level of maturity", commented Dr. Frank Morich, Chief Executive Officer of NOXXON. "This event marks NOXXON's transition to a clinical-stage company and represents a major milestone in our continued effort to develop a pipeline of a novel and innovative class of pharmaceuticals to address major medical needs."
Spiegelmer® (L-aptamers) are chemical entities based on synthetic mirror-image oligonucleotides. Thanks to their unique mirror image configuration Spiegelmers® are not metabolized and do not hybridize with native nucleic acids. Spiegelmers® also do not activate the innate immune response via Toll-like receptors and have shown an exceptionally favorable immunogenicity profile in pre-clinical testing.
NOXXON's lead compound NOX-E36 is a new therapeutic modality that specifically targets the pro-inflammatory chemokine Monocyte Chemotactic Protein-1 (MCP-1, also known as CCL2). Previously completed experiments in various animal models of kidney disease demonstrate that treatment with Spiegelmer® MCP-1 antagonists significantly delays the decline in kidney function as well as disease progression. NOXXON is planning to develop NOX-E36 for the treatment of inflammatory kidney diseases including diabetic nephropathy.
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