ExcellGene and Kühner achieved milestone in development of novel 250 Liter mammalian cell culture bioreactors
As part of a long-term partnership the two companies disclose the successful conclusion of the task of growing mammalian cells for the production of recombinant proteins in an orbitally shaken bioreactor. The mechanism of orbital shaking allows for efficient mixing of suspension cultures, while oxygenating cells through the head space. The cylindrical vessel contains a disposable, sterile bag with appropriate connection tubes for seeding, feeding, gas supply and harvesting of the culture.
The principles of orbital shaking technology with cylindrical vessels at smaller scale (50 ml to 10 Liter) has been object of preceding research and development at the two companies, and data obtained have shown that oxygen can be transferred to cells in such reactors as efficiently, if not more efficiently than any other bioreactor system used for animal cells so far. Cell culture data obtained from pilot experiments executed at ExcellGene have shown that growth and productivity from these reactors, now shown up to a scale of 200 Liters, are equivalent to those of fully instrumented non-disposable, glass or stainless steel stirred bioreactors.
Most read news
Other news from the department research and development
These products might interest you
Biostat STR by Sartorius
Biostat STR Generation 3 Bioreactors
Engineered for Ultimate Upstream Performance
Ambr® 250 HT Consumables by Sartorius
Efficient bioprocesses with single-use bioreactors
Minimise cleaning effort and maximise flexibility for cell and microbial cultures
Ambr® 250 Modular by Sartorius
Mini bioreactors for cell and gene therapies with high scalability
Maximise your process development with reliable single-use vessels
Brooks Instrument SLA Biotech-Serie by Brooks Instrument
Control bioprocesses efficiently and precisely with flow controllers for biotechnology applications
The SLA Biotech series has been developed specifically for the requirements in bioprocesses
Flexcell Systems by Dunn
Flexcell Cell Stretching Bioreactors for Life Science Research
Used in over 1300 laboratories worldwide, and cited in over 4000 research publications
SLAMf Biotech-Serie Massendurchflussregler by Brooks Instrument
SLAMf Mass Flow Controllers Designed Specifically for Biotech (IP66 / NEMA 4X)
Special equipment for biotech process plants, suitable for splash water and high-pressure cleaning
Get the life science industry in your inbox
From now on, don't miss a thing: Our newsletter for biotechnology, pharma and life sciences brings you up to date every Tuesday and Thursday. The latest industry news, product highlights and innovations - compact and easy to understand in your inbox. Researched by us so you don't have to.
Most read news
More news from our other portals
See the theme worlds for related content
Topic world Cell culture technology
Cell culture technology is a central pillar in biotechnological and pharmaceutical research and development. It enables the growth and maintenance of cells under controlled laboratory conditions, providing a window into the molecular and cellular processes of life.
Topic world Cell culture technology
Cell culture technology is a central pillar in biotechnological and pharmaceutical research and development. It enables the growth and maintenance of cells under controlled laboratory conditions, providing a window into the molecular and cellular processes of life.