At what point do we start to age?

Preprogrammed aging: gene-controlled growth in youth drives aging of blood stem cells in late life

20-Jun-2022 - Throughout one’s life, the blood is constantly being replenished from blood stem cells. However, these cells lose their functionality in old age. Researchers at the Leibniz Institute on Aging – Fritz Lipmann Institute (FLI) have now found a gene mechanism that is responsible for the aging of ...

Sartorius acquires majority stake in CellGenix

Portfolio expanded by cell culture components, such as growth factors, cytokines, and media

05-Jul-2021 - The life science group Sartorius, through its subgroup Sartorius Stedim Biotech, has acquired a majority stake in the reagent manufacturer CellGenix GmbH. The company based in Freiburg, Germany, and with a sales subsidiary near the biotechnology hub in Boston, Massachusetts USA, produces and ...

Growth factors in single cells counted for the first time

26-Feb-2019 - Whether healthy or diseased, human cells exhibit behaviors and processes that are largely dictated by growth factor molecules, which bind to receptors on the cells. For example, growth factors tell the cells to divide, move, and when to die--a process known as apoptosis. When growth factor levels ...

Helping certain breast cancer patients with a 3 in 1 molecule

23-Mar-2018 - A newly designed three-part molecule could be the one answer patients with a certain form of breast cancer are looking for, scientists report. This chimera, created by a team at the Georgia Cancer Center, has the ability to simultaneously decrease the expression of three growth factors that are ...

Engineered cartilage template to heal broken bones

12-Mar-2018 - A team of UConn Health researchers has designed a novel, hybrid hydrogel system to help address some of the challenges in repairing bone in the event of injury. The UConn Health team, led by associate professor of orthopedic surgery Syam Nukavarapu , described their findings. There are over 200 ...

Potent parasite protein - New therapeutic options for inflammatory bowel conditions?

24-Nov-2017 - A single protein from a worm parasite may one day offer new therapeutic options for treating inflammatory bowel diseases like Crohn’s or Ulcerative Colitis, that avoid the potentially serious side effects of current immunosuppressant medications. The study demonstrates the discovery of a distinct ...

Mistakes in how proteins of the ear are built contribute to early hearing loss

30-Oct-2017 - From the moment a baby is born, they are put through a battery of screenings to test for all sorts of characteristics, which includes the sense of hearing. One in 500 newborns fail their newborn hearing screens and are diagnosed with hearing loss, making this the most prevalent sensory deficit in ...

Cell senescence is regulated by innate DNA sensing

02-Aug-2017 - Cells in the body or in cultures eventually stop replicating. This phenomenon is called "senescence" and is triggered by shortening of telomeres, oxidative stress or genetic damage to the cells, either acute or simply due to the cell growing "old". Understanding the causes and impact of ...

Colon cancer nuclear pore dynamics are captured by HS-AFM

04-Jul-2017 - One of the key reasons for cancer mortality is caused by the highly invasive behaviour of cancer cells, which is often due to aggressive metastasis. Metastasis is facilitated by various growth factors and cytokines secreted from cells of the immune system, which operate through various signaling ...

Sugar-coated nanomaterial excels at promoting bone growth

21-Jun-2017 - There hasn't been a gold standard for how orthopaedic spine surgeons promote new bone growth in patients, but now Northwestern University scientists have designed a bioactive nanomaterial that is so good at stimulating bone regeneration it could become the method surgeons prefer. While studied in ...