Whipple's disease

Whipple's disease is a rare, systemic infectious disease caused by the bacterium Tropheryma whipplei.^[1] First described by George Hoyt Whipple in 1907^[2][3] and commonly considered a gastrointestinal disorder, Whipple's disease primarily causes malabsorption but may affect any part of the body including the heart, lungs, brain, joints, and eyes. Weight loss, diarrhea, joint pain, and arthritis are common presenting symptoms, but the presentation can be highly variable and approximately 15% of patients do not have these classic signs and symptoms.^[4]. Whipple's disease is significantly more common in men, with a striking 87% of patients being male.^[5]. When recognized and treated, Whipple's disease can usually be cured with long-term antibiotic therapy; untreated the disease is ultimately fatal.

Additional recommended knowledge

How to quickly check pipettes?

What is the Correct Way to Check Repeatability in Balances?

Weighing the right way

Symptoms

• arthritis or arthralgia
• malabsorption
• intestinal lipodystrophy (accumulation of fatty deposits in lymph nodes of the intestine)
• lymphadenopathy
• abdominal pain
• diarrhea
• fever
• melanoderma
• neurological symptoms
  • cognitive changes
  • nystagmus

Diagnosis

Common clinical signs and symptoms of Whipple's disease include weight loss, diarrhea, joint pain or arthritis, fever, and adenopathy. Diagnosis is made by intestinal biopsy, which reveals presence of the organism as PAS-positive macrophage inclusions. Immunohistochemical staining for antibodies against T. whipplei has been used to detect the organism in a variety if tissues, and a confirmatory PCR-based assay is also available.

Endoscopy of the duodenum and jejunum can reveal pale yellow shaggy mucosa with erythematous eroded patches in patients with classic intestinal Whipple's disease, and small bowel X-rays may show some thickened folds.

Treatment

Treatment is with penicillin, ampicillin, tetracycline or co-trimoxazole for 1 -2 years.^[4] Any treatment lasting less than a year has an approximate relapse rate of 40%. In the January 4, 2007 issue of the New England Journal of Medicine, Fenollar et al suggest the use of doxycycline with hydroxychloroquine for 12 to 18 months. Sulfonamides (Sulfadiazine or Sulfamethoxazole) should be added for treatment of neurological symptoms.^[5]

References