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Ventrolateral preoptic nucleus



The ventrolateral preoptic nucleus (VLPO) is a group of neurons in the hypothalamus. They are primarily active during sleep, and inhibit other neurons that are involved in wakefulness. The VLPO neurons release the inhibitory neurotransmitters galanin and GABA to inhibit the monaminergic cell groups in the locus coeruleus, the raphe nucleus, and the tuberomammillary nucleus [1].

References

  1. ^ Saper, C. B., Scammell, T. E., & Lu, J. (2005). "Hypothalamic regulation of sleep and circadian rhythms.". Nature 437: 1257-1264.
  2. ^ Gallopin T, Luppi PH, Cauli B, Urade Y, Rossier J, Hayaishi O, Lambolez B, Fort P. (2005). "The endogenous somnogen adenosine excites a subset of sleep-promoting neurons via A2A receptors in the ventrolateral preoptic nucleus". Neuroscience. PMID 16039802.
  3. ^ Scammell T, Gerashchenko D, Urade Y, Onoe H, Saper C, Hayaishi O. (1998). "Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D2". Proc Natl Acad Sci U S A. PMID 9636223.

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=16039802&dopt=AbstractPlus

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Ventrolateral_preoptic_nucleus". A list of authors is available in Wikipedia.
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