To use all functions of this page, please activate cookies in your browser.
my.bionity.com
With an accout for my.bionity.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
- My watch list
- My saved searches
- My saved topics
- My newsletter
VMAT2
The Vesicular Monoamine Transporter 2 or VMAT2 is an integral membrane protein that acts to transport monoamines—particularly neurotransmitters such as dopamine, norepinephrine,serotonin, and histamine—from cellular cytosol into synaptic vesicles. Additional recommended knowledge
Binding sites and ligandsOne binding site is that of DTBZ. Lobeline binds at this site. At a distinct site dextroamphetamine binds. Its activity at VMAT2 is a crucial part of its monoamine releasing action. Impairment and dysfunctionCocaine users display a marked reduction in VMAT2 immunoreactivity. Sufferers of cocaine-induced mood disorders displayed a significant loss of VMAT2 immunoreactivity, this might reflect damage to striatal dopamine fibers. These neuronal changes could play a role in causing disordered mood and motivational processes in more severely addicted users.[1] "God gene"Geneticist Dean Hamer identified the VMAT2 gene as correlating with spirituality using data from a smoking survey, which included questions intended to measure "self-transcendence". Hamer performed the spirituality study on the side, independently of the National Cancer Institute smoking study. His findings were published in the mass-market book The God Gene: How Faith Is Hard-Wired Into Our Genes.[2][3] According to Carl Zimmer, Hamer's study has not been academically published and depends on a minor statistical variance.[4] See also
References
|
|||||||||||||||||||||||||||||||||||
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "VMAT2". A list of authors is available in Wikipedia. |