UGT2B7

UGT2B7 (UDP-Glucuronosyltransferase-2B7) is a phase II metabolism isoenzyme found to be active in the liver, kidneys, epithelial cells of the lower gastrointestinal tract and also has been reported in the brain.

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This enzyme is located on the endoplasmic reticulum and nuclear membranes of cells. Its function is to catalyse the conjugation of a wide variety of lipophilic aglycon substrates with glucuronic acid, using uridine diphosphate glucuronic acid.

UGT2B7 is the major enzyme isoform for the metabolism of Morphine to the main metabolites, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G).^[1]

References

1. ^ Coffman B, Rios G, King C, Tephly T (1997). "Human UGT2B7 catalyzes morphine glucuronidation". Drug Metab. Dispos. 25 (1): 1-4. PMID 9010622.