two pore segment channel 1
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Identifiers
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Symbol
| TPCN1
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Entrez
| 53373
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HUGO
| 18182
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OMIM
| 609666
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RefSeq
| NM_017901
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UniProt
| Q9ULQ1
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Other data
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Locus
| Chr. 12 q24.21
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two pore segment channel 2
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Identifiers
|
Symbol
| TPCN2
|
Entrez
| 219931
|
HUGO
| 20820
|
RefSeq
| NM_139075
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UniProt
| Q8NHX9
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Other data
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Locus
| Chr. 11 q13.1
|
Two-pore channels: This small family of 2 members putatively forms cation-selective ion channels. They are predicted to contain two KV-style six-transmembrane domains, suggesting they form a dimer in the membrane. These channels are related to catsper channels channels and, more distantly, TRP channels.
Membrane transport protein: ion channels |
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Ca2+: Calcium channel | Voltage-dependent calcium channel (L-type/Cavα(1.1, 1.2, 1.3, 1.4), N-type, P-type/Cavα(2.1), Q-type, R-type, T-type, β-subunits (β1, β2, β4), γ-subunits (γ2) • Inositol triphosphate receptor • Ryanodine receptor • Cation channels of sperm • Two-pore channel |
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Na+: Sodium channel | Navα (1.1, 1.2, 1.4, 1.5, 1.7, 1.9) • Navβ (1, 3, 4) • Epithelial sodium channel |
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K+: Potassium channel | Voltage-gated (Kvα (1.1, 1.2, 1.3, 1.4, 1.5, 2.1, 4.2, 4.3, 7.1, 7.2, 7.3, 7.4, 10.1, 11.1/hERG) • Kvβ (1, 2), Shaker gene, KCNE1) • Calcium-activated (BK channel, SK channel, SK3) • Inward-rectifier Kir (1.1, 2.1, 2.2, 2.3, 3.1, 3.2, 3.4, 4.1, 4.2, 6.1, 6.2)) • Tandem pore domain K2P (1, 2, 3, 4, 6, 9) |
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Cl-: Chloride channel | Cystic fibrosis transmembrane conductance regulator |
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Porin | Aquaporin (1, 2, 3, 4) • Voltage-dependent anion channel (1) |
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Cations: TRP | TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2)• TRPV (1, 2, 3, 4, 5, 6) |
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Other/general | Voltage-gated ion channel • Ligand-gated ion channel • Cyclic nucleotide-gated ion channel (α1, α3, β3, H1, H2, H4) • Stretch-activated ion channel |
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