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Tuftsin



Tuftsin
Identifiers
CAS number 9063-57-4
PubChem 24780
MeSH Tuftsin
Properties
Molecular formula C21H40N8O6
Molar mass 500.593 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Tuftsin is a tetrapeptide (Thr-Lys-Pro-Arg) produced by enzymatic cleavage of the Fc-domain of the heavy chain of immunoglobulin G. It is produced primarily in the spleen.

Contents

Function

Its biological activity is related primarily to the immune system function.

Tuftsin binds to specific receptors on the surface of macrophages and polymorphonuclear leukocytes, stimulating their migration, phagocytic, bactericidal, and tumoricidal activity. It also influences antibody formation.

Pathology

Tuftsin deficiency, either hereditary or following splenectomy, results in increased susceptibility to certain infections. [1]

Clinical significance

Tuftsin has been chemically synthesized and it is considered for use in immunotherapy.

History

Tuftsin was first identified in 1970 by scientists Najjar and Nishioka[2]. It was named after Tufts University where the peptide was discovered.

References

  1. ^ Online 'Mendelian Inheritance in Man' (OMIM) 191150 - "Tuftsin deficiency"
  2. ^ Najjar V, Nishioka K (1970). ""Tuftsin": a natural phagocytosis stimulating peptide". Nature 228 (5272): 672-3. PMID 4097539.

See also

  • Paraprotein
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Tuftsin". A list of authors is available in Wikipedia.
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