Tuberoinfundibular pathway
The tuberoinfundibular pathway refers to a population of dopamine neurons in the arcuate nucleus of the mediobasal hypothalamus (the 'tuberal region') that project to the median eminence (the 'infundibular region'). It is one of the four major dopamine pathways in the brain. Dopamine released at this site regulates the secretion of prolactin from the anterior pituitary gland.
Additional recommended knowledge
Some antipsychotic drugs block dopamine in the tuberoinfundibular pathway, which can cause an increase in blood prolactin levels (hyperprolactinemia). This can cause abnormal lactation (even in men), disruptions to the menstrual cycle in women, visual problems, headache and sexual dysfunction.
Other major dopamine pathways include:
See also
Brain: telencephalon (cerebrum, cerebral cortex, cerebral hemispheres) |
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Primary sulci/fissures | Medial longitudinal, Lateral, Central, Parietoöccipital, Calcarine, Cingulate, Callosal Collateral fissure |
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Frontal lobe | Precentral gyrus (Primary motor cortex, 4), Precentral sulcus, Superior frontal gyrus/Frontal eye fields (6, 8, 9), Middle frontal gyrus (46), Inferior frontal gyrus (44-Pars opercularis, 45-Pars triangularis), Orbitofrontal cortex (10, 11, 12, 47) |
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Parietal lobe | Somatosensory cortex (Primary (1, 2, 3, 43), Secondary (5)), Precuneus (7m), Parietal lobules (Arcuate fasciculus/Superior (7l), Inferior (40)), Angular gyrus (39), Intraparietal sulcus, Marginal sulcus |
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Occipital lobe | Primary visual cortex (17), Cuneus, Lingual gyrus, 18, 19 - Lateral occipital sulcus |
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Temporal lobe | Primary auditory cortex (41, 42), Superior temporal gyrus (38, 22), Middle temporal gyrus (21), Inferior temporal gyrus (20), Fusiform gyrus (37) Medial temporal lobe (Amygdala, Hippocampus, Parahippocampal gyrus (27, 28, 34, 35, 36) |
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Cingulate cortex/gyrus | Subgenual area (25), anterior cingulate (24, 32, 33), Posterior cingulate (23, 31), Retrosplenial cortex (26, 29, 30), Supracallosal gyrus |
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white matter tracts | Corpus callosum (Splenium, Genu, Rostrum, Tapetum), Septum pellucidum, Internal capsule, Corona radiata, External capsule, Olfactory tract, Fornix (Commissure of fornix), Anterior commissure, Posterior commissure Terminal stria Superior and Inferior longitudinal fasciculus, uncinate fasciculus, cingulum, Inferior occipitofrontal fasciculus |
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Basal ganglia | Striatum (Putamen,Caudate nucleus, Nucleus accumbens), Globus pallidus, Claustrum, Subthalamic nucleus, Substantia nigra |
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Other | Insular cortex Olfactory bulb, Anterior olfactory nucleus Septal nuclei Basal optic nucleus of Meynert |
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Some categorizations are approximations, and some Brodmann areas span gyri. |
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