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Transforming growth factorTransforming growth factor (sometimes referred to as Tumor growth factor, or TGF) is used to describe two classes of polypeptide growth factors, TGFα and TGFβ. Additional recommended knowledgeThe name "Transforming Growth Factor" is somewhat arbitrary, since the two classes of TGFs are not structurally or genetically related to one another, and they act through different receptor mechanisms. Furthermore, they do not always induce cellular transformation, and are not the only growth factors that induce cellular transformation. Types
FunctionThese proteins were originally characterized by their capacity to induce oncogenic transformation in a specific cell culture system, rat kidney fibroblasts. Application of the transforming growth factors to normal rat kidney fibroblasts induces the cultured cells to proliferate and overgrow, no longer subject to the normal inhibition caused by contact between cells. See also
Categories: Cell signaling | Signal transduction | Growth factors |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Transforming_growth_factor". A list of authors is available in Wikipedia. |