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Toxicophore
Additional recommended knowledgeA toxic substance exerts its toxicity through interaction (covalent bonding or oxidation) with a cellular macromolecule, such as a protein or DNA. This causes changes in the normal cellular biochemistry and physiology eliciting toxic effects. Occasionally, the toxicophore requires bioactivation, modified by an enzyme, to produce a more reactive chemical species that is able to covalently bind to cellular macromolecules. Generally, different chemical compounds that contain the same toxicophore elicit similar toxic effects within the same organ system or area of the body.[1] References
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Toxicophore". A list of authors is available in Wikipedia. |