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Thiamine triphosphate
Thiamine triphosphate (ThTP) is found in most organisms, bacteria, fungi, plants and animals.[1] Additional recommended knowledgeFunctionIt has been proposed that ThTP has a specific role in nerve excitability[2] but this has never been confirmed and recent results suggest that ThTP probably plays a role in cell energy metabolism.[1] [3] Moreover some results suggesting that ThTP deficiency is responsible for subacute necrotizing encephalopathy or Leigh's disease have not been confirmed. [4] In E. coli, ThTP is accumulated in the presence of glucose during amino acid starvation.[1] [3] On the other hand, suppression of the carbon source leads to the accumulation, of adenosine thiamine triphosphate (AThTP). In mammals, ThTP is hydrolyzed by a specific thiamine triphosphatase.[5] HistoryThiamine triphosphate (ThTP) was chemically synthesized in 1948 at a time when the only organic triphosphate known was ATP.[6] The first claim of the existence of ThTP in living organisms was made in rat liver,[7] followed by baker’s yeast.[8] Its presence was later confirmed in rat tissues[9] and in plants germs, but not in seeds, where thiamine was essentially unphosphorylated.[10] In all those studies, ThTP was separated from other thiamine derivatives using a paper chromatographic method, followed by oxidation in fluorescent thiochrome compounds with ferricyanide in alkaline solution. This method is at best semi-quantitative, and the development of liquid chromatographic methods suggested that ThTP represents far less than 10 % of total thiamine in animal tissues[11] and bacteria.[12] References
Categories: Biomolecules | Vitamins | Organophosphates |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Thiamine_triphosphate". A list of authors is available in Wikipedia. |