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Tenase



The tenase complex is formed by the activated forms of the blood coagulation factors factor VIII and factor IX. It forms on a phospholipid surface in the presence of calcium and is responsible for the activation of factor X.

Tenase" is a contraction of "ten" and the suffix "-ase" used for enzymes

v • d • e
Pathology: hematology (primarily C81-C96/200-208, D45-D47, D50-D77/280-289)
WBCshematological malignancy (lymphoma, leukemia, multiple myeloma), myeloproliferative disease, myelodysplastic syndrome
-cytosis (Agranulocytosis, Leukocytosis, Lymphocytosis, Monocytosis) • -penia (Lymphopenia, Neutropenia)
RBCs/anemia/
hemoglobinopathy		nutritional anemia: Iron deficiency anemia, Plummer-Vinson syndrome, Megaloblastic anemia (Pernicious anemia)
hereditary hemolytic anemia: G6PD Deficiency, Thalassemia, Sickle-cell disease/trait, Hereditary spherocytosis, Hereditary elliptocytosis, Hereditary stomatocytosis

acquired hemolytic anemia: Autoimmune (Warm), HUS, MAHA, PNH, PCH

aplastic anemia: Acquired PRCA, Diamond-Blackfan anemia, Fanconi anemia • Sideroblastic anemia • Hemochromatosis
Coagulation/plateletscoagulopathy: DIC • Hemophilia (A/VII, B/IX, C/XI, XIII) • Von Willebrand disease

Purpura: Henoch-Schönlein, ITP (Evans syndrome), TTP

primary hypercoagulable state: Protein C deficiency - Protein S deficiency - Antithrombin III deficiency - Antiphospholipid syndrome - Factor V Leiden

other hemorrhagic conditions: Bernard-Soulier syndrome - Glanzmann's thrombasthenia - Grey platelet syndrome
HistiocytosisWHO-I Langerhans cell histiocytosis - non-Langerhans-cell histiocytosis/WHO-II (Juvenile xanthogranuloma, Hemophagocytic lymphohistiocytosis) - malignant histiocytic disorders/WHO-III (Acute monocytic leukemia, Malignant histiocytosis, Erdheim-Chester disease)
OtherAsplenia/hyposplenism - Methemoglobinemia
v • d • e
Proteins: coagulation
Coagulation factorsintrinsic pathway (FXII, FXI, FIX, FVIII) - extrinsic pathway (Tissue factor, FVII) - common pathway (FX, FV, (Pro)thrombin / FII, Fibrin / FI, FXIII) - HMWK - vWF - Kallikrein
InhibitorsAntithrombin - Protein C - Protein S - Protein Z - ZPI - TFPI
FibrinolysisPlasmin - tPA/urokinase - PAI-1/2 - α2-AP - α2-macroglobulin - TAFI
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Tenase". A list of authors is available in Wikipedia.
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