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Tazobactam


Tazobactam
Systematic (IUPAC) name
(2S,3S,5R)-3-methyl-4,4,7-trioxo-3- (triazol-1-ylmethyl)-4$l^{6}-thia-1-azabicyclo[3.2.0] heptane-2-carboxylic acid
Identifiers
CAS number	89786-04-9
ATC code	J01CG02
PubChem	?
DrugBank	EXPT03012
Chemical data
Formula	C₁₀H₁₂N₄O₅S
Mol. mass	300.289 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Tazobactam is a compound which inhibits the action of bacterial beta-lactamases. It is added to the extended spectrum beta-lactam antibiotic piperacillin to produce Tazocin® or Zosyn®. It broadens the spectrum of piperacillin by making it effective against organisms that express beta-lactamase and would normally degrade piperacillin.

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Tazobactam sodium is a derivative of the penicillin nucleus and is a penicillanic acid sulfone.

v • d • e Antibacterials for systemic use: beta-lactam antibiotics - penicillins (J01C)
Antibiotics	Amoxicillin • Ampicillin • Azlocillin • Carbenicillin • Cloxacillin • Dicloxacillin • Flucloxacillin • Mezlocillin • Nafcillin • Piperacillin • Pivampicillin • Ticarcillin
Beta-lactamase inhibitors	Sulbactam • Tazobactam • Clavulanic acid
Combinations	Ampicillin/sulbactam (Sultamicillin) • Co-amoxiclav