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Tazarotene


Tazarotene
Systematic (IUPAC) name
ethyl 6-[2-(4,4-dimethylthiochroman-6-yl) ethynyl] pyridine-3-carboxylate
Identifiers
CAS number	118292-40-3
ATC code	D05AX05
PubChem	5381
DrugBank	APRD01246
Chemical data
Formula	C₂₁H₂₁NO₂S
Mol. mass	351.463 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	>99%
Metabolism	?
Half life	19 Hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	X (U.S.)
Legal status	Prescription Only
Routes	Topical

Tazarotene (marketed as Tazorac®, Avage® and Zorac®) is a prescription topical retinoid sold as a cream or gel. This medication is approved for treatment of psoriasis, acne, and sun damaged skin (photodamage). It is commonly sold in two concentrations: 0.05% and 0.1%.

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Common side effects include worsening of acne, dry skin, itchiness, redness and in some cases extreme drying and cracking of skin. For most patients these side effects are uncomfortable but mild and decrease markedly after the first 2–4 weeks of use.

For best results dermatologists recommend applying the cream or gel once daily before bedtime after washing the face with a mild soap.

v • d • e Antipsoriatics (D05)
Topical: tars	Tar
Topical: antracens	Dithranol
Topical: psoralens	Trioxysalen - Methoxsalen
Topical: other	Fumaric acid - Calcipotriol - Calcitriol - Tacalcitol - Tazarotene
Systemic: psoralens	Trioxysalen - Methoxsalen - Bergapten
Systemic: retinoids	Etretinate - Acitretin

v • d • e Carotenoids
Carotenes:	Lycopene · Carotene · Beta-carotene · Alpha-carotene · Phytofluene · Neurosporene · Phytoene
Retinoids:	Acitretin · Alitretinoin · Bexarotene · Etretinate · Fenretinide · Isotretinoin · Retinaldehyde · Tazarotene · Vitamin A (Retinol, Tretinoin)
Xanthophylls:	Astaxanthin · Canthaxanthin · Fucoxanthin · Lutein · Zeaxanthin · Cryptoxanthin · Rubixanthin