Tangeritin

Tangeritin is a polymethoxylated flavone that is found in tangerine and other citrus peels.

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Although few randomized, double-blind human studies have been done, animal research shows the potential of tangeritin as a cholesterol lowering agent ^[1]. A hamster study showed potential protective effects against Parkinson's disease ^[2]. Tangeritin shows potential as an anti cancer agent. In in vitro studies, tangeritin appears to counteract some of the adaptations of cancer cells. Tangeritin strengthens the cell wall and protects it from invasion. Tangeritin induced apoptosis in leukemia cells while sparing normal cells ^[3]. It counteracts tumor suppression of gap junction intercellular signaling ^[4]. It acts to freeze cancer cells in phase G1 of the cell cycle, preventing replication. In summary, in vitro studies show antimutagenic ^[5], antiinvasive ^[6] and antiproliferative ^[7] effects. One caveat is that tangeritin appears to counteract the anticancer drug tamoxifen and to suppress the activity of natural killer cells ^[8].

Tangeritin is commercially available as a dietary supplement.

See also

• Apigenin
• Luteolin

References

1. ^ Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia
2. ^ Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease
3. ^ Citrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes
4. ^ http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9103293&query_hl=2&itool=pubmed_DocSum
5. ^ http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8693033&query_hl=2&itool=pubmed_DocSum
6. ^ http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2924447&query_hl=2&itool=pubmed_DocSum
7. ^ http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1998943&query_hl=2&itool=pubmed_DocSum
8. ^ http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11056327&query_hl=2&itool=pubmed_docsum