Syphilis TPHA test

The Syphilis TPHA test is a classic, indirect hemagglutination test used for the detection and titration of antibodies against the causative agent of syphilis,Treponema pallidum.

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In the test red blood cells (erythrocytes) are sensitized with antigens from T. pallidum. The erythrocytes will then aggregate together to form distinctive patterns on the surface of a microplate wells when exposed to syphilitic serum.

False Positives are common in this test. This is typically caused by antibodies directed against other non-pathogenic or non target treponemas, such as T. pallidum subsp endemicum, T. pallidum subsp pertenue, and T. carateum. These antibodies can be adsorbed out of the test sample by a variety of methods thereby reducing false positives for syphilis.