TCF7L2 also known as TCF4 is a protein acting as a transcription factor. A variant of the protein is linked to higher risk to develop type 2 diabetes.
TCF7L2
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Identifiers
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Symbol
| TCF7L2
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Alt. Symbols
| TCF4
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Entrez
| 6934
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HUGO
| 11641
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OMIM
| 602228
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PDB
| 2GL7
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RefSeq
| NM_030756.2
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UniProt
| Q5JRY4
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Other data
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Locus
| Chr. 10 q25.3
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Additional recommended knowledge
Function
TCF7L2 is a transcription factor influencing the transcription of several genes thereby exerting a large variety of functions in the cell. It is a member of the Wnt signaling pathway. Stimulation of the pathway leads to the association of β-catenin with TCF7L2 and BCL9 in the nucleus, which in turn results in the activation of Wnt target genes.
Disease implications
TCF7L2 is implied in a large variety of diseases. Several single nucleotide polymorphisms are associated with type 2 diabetes. In European populations it was found to be a major determinant of type 2 risk.
A frameshift mutation of TCF7L2 is implied in colorectal cancer. Variants of the gene are most likely involved in many other cancer types. See PubMed GeneRIFs for more information [1].
Links
- TCF7L2 here called TCF4 features on this Wnt pathway web site: Wnt signalling molecules TCFs
- Structure determination of TCF7L2: PDB entry 2GL7 and related publication on PubMed
- PubMed GeneRIFs (summaries of related scientific publications) - [2]
- Weizmann Institute GeneCard for TCF7L2
Transcription factors and intracellular receptors |
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(1) Basic domains |
(1.1) Basic leucine zipper (bZIP) |
Activating transcription factor (1, 2, 3, 4, 5, 6) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3) • GABPA • MAF (B, F, G, K) • NRL • NRF1 • XBP1 |
(1.2) Basic helix-loop-helix (bHLH) |
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BMAL (ARNTL, ARNTL2) • CLOCK • HIF (1A, 3A) • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • NEUROD1 • Twist • USF1 |
(1.3) bHLH-ZIP |
Myc • MITF • SREBP (1, 2) |
(1.6) Basic helix-span-helix (bHSH) |
AP-2 |
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(2) Zinc finger DNA-binding domains |
(2.1) Nuclear receptor (Cys4) |
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP) |
(2.2) Other Cys4 |
GATA (1, 2, 3, 4, 5, 6) |
(2.3) Cys2His2 |
General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH: 1, 2) • GLI-Krüppel family (1, 2, 3, YY1) • KLF (2, 4, 5, 6, 10, 11, 12, 13) • Sp1 • zinc finger (3, 35, 43, 146, 148, 165, 217, 268, 281, 350) • Zbtb7 (7A) • ZBT (16, 17, 33) |
(2.4) Cys6 |
HIVEP1 |
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(3) Helix-turn-helix domains |
(3.1) Homeo domain |
ARX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C6, C8, C9, C13, D1, D3, D4, D9, D10, D11, D12, D13) • NANOG • NKX (2-1, 2-5, 3-1) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) |
(3.2) Paired box |
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9) |
(3.3) Fork head / winged helix |
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, L2, M1, N3, O3, O4, P1, P2, P3) |
(3.4) Heat Shock Factors |
HSF1 |
(3.5) Tryptophan clusters |
ELF (4, 5) • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB |
(3.6) TEA domain |
transcriptional enhancer factor 1, 2 |
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(4) β-Scaffold factors with minor groove contacts |
(4.1) Rel homology region |
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (5, C1, C2, C3, C4) |
(4.2) STAT |
STAT (1, 2, 3, 4, 5, 6) |
(4.3) p53 |
p53 |
(4.4) MADS box |
Mef2 (A, B, C, D) • SRF |
(4.7) High mobility group |
HNF (1A, 1B) • LEF1 • SOX (3, 4, 6, 9, 10, 13, 18) • SRY • SSRP1 |
(4.10) Cold-shock domain |
CSDA |
(4.11) Runt |
CBF (RUNX1, RUNX2, RUNX3) |
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(0) Other transcription factors |
(0.2) HMGI(Y) |
HMGA (1, 2) |
(0.3) Pocket domain |
Rb • RBL1 • RBL2 |
(0.6) Miscellaneous |
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • Rho/Sigma • R-SMAD |
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