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Sulbutiamine


Sulbutiamine
Systematic (IUPAC) name
[4-[(4-amino-2-methyl-pyrimidin-5-yl)methyl-formyl- amino]-3-[2-[(4-amino-2-methyl-pyrimidin-5-yl)methyl- formyl-amino]-5-(2-methylpropanoyloxy)pent-2-en-3- yl]disulfanyl-pent-3-enyl] 2-methylpropanoate
Identifiers
CAS number	3286-46-2
ATC code	A11DA02
PubChem	71124
Chemical data
Formula	C₃₂H₄₆N₈O₆S₂
Mol. mass	702.89 g/mol
SMILES	search in eMolecules, PubChem
Synonyms	Arcalion, bisibuthiamine, youvitan
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	5 hours
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Oral

Sulbutiamine (brand name: Arcalion®) is a precursor to thiamine (i.e., vitamin B₁). It is indicated for the treatment of asthenia.^[1] Furthermore, the ability of sulbutiamine to reduce fatigue is considered desirable by athletes, and it is available for over-the-counter sale as a nutritional supplement. Additionally, the demonstrated ability of sulbutiamine to improve memory in rats^[2] and patients of schizophrenia^[2] suggests that it is a nootropic.

Additional recommended knowledge

How to quickly check pipettes?

Daily Sensitivity Test

Weighing the right way

Effects

Sulbutiamine reduces fatigue, memory difficulties, intellectual tiredness and may speed convalescence.^[3]

Dosage

Sulbutiamine is sometimes supplied in 200 mg tablets. The proper therapeutic dosage has been reported to be 12.5 mg/kg,^[2] which corresponds to 850 mg for a 68 kg (150 lb) person. However, it should be noted that dosage recommendations vary; the manufacturer of Arcalion, for example, recommends no more than 600 mg per day.

References

^ Shah SN; Sulbutiamine Study Group (2003). "Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia.". J Assoc Physicians India 51: 891–5. PMID 14710977.
^ ^a ^b ^c Bizot JC, Herpin A, Pothion S, Pirot S, Trovero F, Ollat H (2005). "Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task.". Prog Neuropsychopharmacol Biol Psychiatry 29 (6): 928–35. PMID 15951087.
^ http://www.serdiapharma.com/about/arcalion.asp

v • d • e Vitamins (A11)
fat soluble	A (Retinol, Beta-carotene, Tretinoin, Alpha-carotene) - D (Ergocalciferol, Cholecalciferol, Dihydrotachysterol, Calcitriol, Calcidiol) - E (Tocopherol, Tocotrienol) - K (Naphthoquinone, Phylloquinone/K1, Menatetrenone/K2)
water soluble: B vitamins	B₁ (Thiamine, Sulbutiamine, Benfotiamine) - B₂ (Riboflavin) - B₃ (Niacin, Nicotinamide) - B₅ (Pantothenic acid, Dexpanthenol, Pantethine) - B₆ (Pyridoxine, Pyridoxal phosphate) - B₇ (Biotin) - B₉ (Folic acid) - B₁₂ (Cyanocobalamin, Hydroxocobalamin, Methylcobalamin, Cobamamide)
water soluble: other	C (Ascorbic acid) - Choline

v • d • e Psychoanaleptics: psychostimulants, agents used for ADHD and nootropics (N06B)
Centrally acting sympathomimetics	Amphetamine - Amphetaminil - Atomoxetine - Dexamphetamine - Dextromethamphetamine - Fencamfamin - Fenozolone - Fenetylline - Methylphenidate - Mesocarb - Pemoline - Pipradrol - Prolintane
Xanthine derivatives	Caffeine - Propentofylline
Racetams	Aniracetam - Oxiracetam - Piracetam - Pramiracetam
Eugeroics	Adrafinil - Modafinil
Other psychostimulants and nootropics	Acetylcarnitine - Citicoline - Cyprodenate - Idebenone - Deanol - Dimebon - Fipexide - Linopirdine - Meclofenoxate - Nizofenone - Pirisudanol - Pyritinol - Sulbutiamine - Vinpocetine

Category: Nootropics

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Sulbutiamine". A list of authors is available in Wikipedia.