Sialidase

Sialidase, accession number PF02973 is a widespread enzyme that catalyzes the hydrolysis of terminal acylneuraminic residues from oligosaccharides, glycolipids and glycoproteins. Also called neuraminidase.

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It is present as a surface antigen in myxo viruses, hence sialidase inhibitors are used in anti-viral drugs.^[1]

Deficiency of this enzyme, an autosomal recessive trait, causes sialidosis; enzyme activity is also lacking in galactosialidosis. The EC nomenclature is exo-α-sialidase.

Genes

• NEU1, NEU2, NEU3, NEU4

References