Short-chain dehydrogenase

short chain dehydrogenase
Identifiers
Symbol	adh_short
Pfam	PF00106
InterPro	IPR002198
SCOP	1hdc
OPM family	127
OPM protein	1xu7
Available PDB structures: 1edoA:78-246 1zbqA:10-183 1gz6A:10-183 1gcoA:8-177 1g6kB:8-177 1geeF:8-177 1rwbE:8-177 1hxhC:8-171 1nfqA:8-172 1nfrA:8-172 1nffB:8-172 2hsdA:7-171 1hdcC:7-171 1zk0A:8-163 1zk3B:8-163 1zk4A:8-163 1zjzA:8-163 1zk1A:8-163 1zk2A:8-163 1zjyA:8-163 1nxqA:8-163 2bglA:17-186 2bgkB:17-186 2bgmA:17-186 1iy8D:14-184 1k2wA:6-171 1uzoA:6-171 1gegC:3-171 1wmbB:5-174 1x7gA:7-176 1w4zB:7-176 1xr3A:7-176 1x7hA:7-176 1e3wD:11-187 1e3sC:11-187 1e6wD:11-187 1u7tB:11-187 1so8A:11-187 1f67A:11-187 1uayA:3-167 1yxmB:19-157 2ag5D:7-166 1dohA:30-197 1g0nA:30-197 1g0oA:30-197 1ybvA:30-197 1ja9A:22-189 1vl8A:10-179 1ydeM:10-173 1spxA:7-153 1xkqA:7-181 1xhlB:7-179 1wntB:8-168 1pr9A:8-168 1cydB:8-168 2bd0C:3-177 1h5qL:12-188 1fdvD:4-175 1iol :4-175 1fdw :4-175 3dheA:4-175 1fduD:4-175 1equA:4-175 1qywA:4-175 1i5rA:4-175 1dhtA:4-175 1qyxA:4-175 1fdt :4-175 1a27 :4-175 1bhs :4-175 1jtvA:4-175 1qyvA:4-175 1fds :4-175 1xg5A:12-185 1wmaA:6-144 1n5dA:6-140 1xq1A:15-183 1ipeA:10-178 2ae2A:10-178 1ipfB:10-178 2ae1 :10-178 1ae1A:22-190 1bdb :6-174 1o5iB:8-160 1yb1B:37-204 2belC:35-202 1xu7D:35-202 1xu9D:35-202 1y5rA:35-202 1y5mA:35-202 1xseA:35-202 2bfmB:7-213 1e92A:7-213 1w0cE:7-213 2bfoD:7-213 2bf7B:7-213 2bfpB:7-213 2bfaD:7-213 1e7wB:7-213 1p33B:8-214 1mxfC:12-201 1mxhC:12-201 1w73D:60-229 1w8dB:60-229 1snyA:2-188 1yo6C:4-155 1z6zB:8-189 1oaa :9-190 1nasA:9-190 1sep :9-190 1mg5A:9-172 1b14B:6-170 1sbyB:6-170 1a4uB:6-170 1b15A:6-170 1b16B:6-170 1b2lA:6-170 1fk8A:2-129 1fjhA:2-129 1jvfA:7-177 1jw7A:7-177 1dirD:8-166 1dhr :8-166 1hdr :11-169 1ooeB:4-162

The short-chain dehydrogenases/reductases family (SDR)^[1] is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases. As the first member of this family to be characterised was Drosophila alcohol dehydrogenase, this family used to be called^[2]^[3]^[4] 'insect-type', or 'short-chain' alcohol dehydrogenases. Most member of this family are proteins of about 250 to 300 amino acid residues. Most dehydrogenases possess at least 2 domains^[5], the first binding the coenzyme, often NAD, and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis. Little sequence similarity has been found in the coenzyme binding domain although there is a large degree of structural similarity, and it has therefore been suggested that the structure of dehydrogenases has arisen through gene fusion of a common ancestral coenzyme nucleotide sequence with various substrate specific domains^[5].

Additional recommended knowledge

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Subfamilies

Glucose/ribitol dehydrogenase IPR002347
Insect alcohol dehydrogenase family IPR002424
2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase IPR003560

Human proteins containing this domain

17BHSDI; BDH1; BDH2; CBR1; CBR3; CBR4; DCXR; DECR1; DECR2; DHRS1; DHRS10; DHRS13; DHRS2; DHRS3; DHRS4; DHRS4L2; DHRS7; DHRS7B; DHRS8; DHRS9; DHRSX; FASN; FVT1; HADH2; HPGD; HSD11B1; HSD11B2; HSD17B1; HSD17B10; HSD17B12; HSD17B13; HSD17B2; HSD17B3; HSD17B4; HSD17B6; HSD17B7; HSD17B7P2; HSD17B8; HSDL1; HSDL2; PECR; QDPR; RDH10; RDH11; RDH12; RDH13; RDH14; RDH16; RDH5; RDH8; RDHE2; RDHS; SCDR10; SPR; WWOX;

References

^ Persson B, Krook M, Atrian S, Gonzalez-Duarte R, Jeffery J, Ghosh D, Jornvall H (1995). "Short-chain dehydrogenases/reductases (SDR)". Biochemistry 34 (18): 6003-6013. PMID 7742302.
^ Villarroya A, Juan E, Egestad B, Jornvall H (1989). "The primary structure of alcohol dehydrogenase from Drosophila lebanonensis. Extensive variation within insect 'short-chain' alcohol dehydrogenase lacking zinc". Eur. J. Biochem. 180 (1): 191-197. PMID 2707261.
^ Persson B, Krook M, Jornvall H (1991). "Characteristics of short-chain alcohol dehydrogenases and related enzymes". Eur. J. Biochem. 200 (2): 537-543. PMID 1889416.
^ Harayama S, Bairoch A, Hartnett C, Rekik M, Ornston LN, Neidle E (1992). "cis-diol dehydrogenases encoded by the TOL pWW0 plasmid xylL gene and the Acinetobacter calcoaceticus chromosomal benD gene are members of the short-chain alcohol dehydrogenase superfamily". Eur. J. Biochem. 204 (1): 113-120. PMID 1740120.
^ ^a ^b Benyajati C, Place AR, Powers DA, Sofer W (1981). "Alcohol dehydrogenase gene of Drosophila melanogaster: relationship of intervening sequences to functional domains in the protein". Proc. Natl. Acad. Sci. U.S.A. 78 (5): 2717-2721. PMID 6789320.

Categories: Protein domains | Single-pass transmembrane proteins

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Short-chain_dehydrogenase". A list of authors is available in Wikipedia.