SORL1

The SORL1 (also known as SORLA, SORLA1, LR11, or sortilin-related receptor, L(DLR class) A repeats-containing) gene is a gene that in humans is predominantly expressed in the central nervous system^[1].

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In January 2007, a group of international researchers published a study^[2] that proposes that the gene SORL1 plays a part in seniors developing Alzheimer's disease, significant across racial and ethnic strata^[3]. The gene Apolipoprotein E (APOE) is still the gene of best prediction for Alzheimer's.^[4].

See also

• Apolipoprotein E

References

1. ^ SORL1 sortilin-related receptor, L(DLR class) A repeats-containing [ Homo sapiens ]. Entrez Gene. United States National Center for Biotechnology Information (10 January 2007). Retrieved on 2007-01-15.
2. ^ Rogaeva, Ekaterina; Meng, Yan; Lee, Joseph H; Gu, Yongjun; Kawarai, Toshitaka; Zou, Fanggeng; Katayama, Taiichi; Baldwin, Clinton T; Cheng, Rong; Hasegawa, Hiroshi; Chen, Fusheng; Shibata, Nobuto; Lunetta, Kathryn L; Pardossi-Piquard, Raphaelle; Bohm, Christopher; Wakutani, Yosuke; Cupples, L Adrienne; Cuenco, Karen T; Green, Robert C; Pinessi, Lorenzo; Rainero, Innocenzo; Sorbi, Sandro; Bruni, Amalia; Duara, Ranjan; Friedland, Robert P; Inzelberg, Rivka; Hampe, Wolfgang; Bujo, Hideaki; Song, You-Qiang; Andersen, Olav M; Willnow, Thomas E; Graff-Radford, Neill; Petersen, Ronald C; Dickson, Dennis; Der, Sandy D; Fraser, Paul E; Schmitt-Ulms, Gerold; Younkin, Steven; Mayeux, Richard; Farrer, Lindsay A; St George-Hyslop, Peter. (14 January 2007). "The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease". Nature Genetics. doi:10.1038/ng1943. Retrieved on 2007-01-15. Advance online publication; Volume/Issue/Page available later
3. ^ Hall, Joseph. "Canadian-led team links gene to Alzheimer's", Toronto Star, 15 January 2007. Retrieved on 2007-01-15. 
4. ^ Wade, Nicholas. "Study Detects a Gene Linked to Alzheimer’s", The New York Times, 15 January 2007. Retrieved on 2007-01-15.