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Ryanodine

Ryanodine

Identifiers
CAS number	15662-33-6
PubChem	5114
MeSH	Ryanodine
Properties
Molecular formula	C₂₅H₃₅NO₉
Molar mass	493.547 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

Ryanodine is a poisonous alkaloid found in the South American plant Ryania speciosa.

Additional recommended knowledge

Daily Sensitivity Test

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The compound has extremely high affinity to the ryanodine receptor, a group of calcium channels found in skeletal and heart muscle cells. It binds with such high affinity to the receptor that it was used as a label for the first purification of that class of ion channels and gave its name to it.

At nanomolar concentrations, ryanodine locks the receptor in a half-open state, whereas it fully closes them at micromolar concentration. The effect of the nanomolar-level binding is that ryanodine causes release of calcium from calcium stores in the sarcoplasmic reticulum leading to massive muscular contractions.