Ruthenium red

Ruthenium red is a Ruthenium containing red staining dye.

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The organic Ruthenium Red is polycationic cell biology reagent that tightly binds to tubulin dimers and Ryanodine receptor. It is a potent inhibitor of intracellular calcium release by Ryanodine receptors at nanomolar concentrations (km ~20 nM). ^[1]

The inorganic dye ammoniated ruthenium oxychloride used in histology to stain aldehyde fixed mucopolysaccharides, is sometimes also called Ruthenium red, and inhibits calcium transport through membrane channels.

References

1. ^ TRIPATHY, LE XU ASHUTOSH, PASEK, DANIEL A., MEISSNER, GERHARD Potential for Pharmacology of Ryanadine Receptor/Calcium Release Channels Ann NY Acad Sci 1998 853: 130-148 [1]