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Ristocetin induced platelet agglutinationThe ristocetin induced platelet aggregation (RIPA) is an in vitro assay for von Willebrand factor activity used to diagnose von Willebrand disease. It has the benefit over the ristocetin cofactor activity in that it can diagnose type 2B vWD and Bernard-Soulier syndrome. Additional recommended knowledgeIn an unknown fashion, the antibiotic ristocetin causes von Willebrand factor to bind the platelet receptor glycoprotein Ib (GpIb), so when ristocetin is added to normal blood, it causes agglutination. In von Willebrand disease, where von Willebrand factor is absent or defective, abnormal agglutination occurs:
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Ristocetin_induced_platelet_agglutination". A list of authors is available in Wikipedia. |