Retinol binding protein 4


Human serum retinol binding protein. From PDB 1RBP.
retinol binding protein, plasma
Identifiers
Symbol	RBP4
Entrez	5950
HUGO	9922
OMIM	180250
RefSeq	NM_006744
UniProt	P02753
Other data
Locus	Chr. 10 q24

Retinol binding protein (RBP coded by the gene RBP4) has recently been described as an adipokine that contributes to insulin resistance in the AG4KO mouse model.^[1]

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It is secreted by adipocytes, and can act as a signal to other cells, when there is a decrease in plasma glucose concentration.^[2]

References

^ Yang, Q. et al. (2005) Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 436:35-362
^ Herman, M.A and Kahn, B.B. (2006) Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. The Journal of Clincial Investigation. 116:1767-1775 link

v • d • e Proteins: carrier proteins
Hormone	Follistatin - Growth hormone binding protein - Insulin-like growth factor binding protein - Neurophysins (Neurophysin I, II) Sex hormone binding globulin/Androgen binding protein - Transcortin - Thyroxine-binding globulin - Transthyretin
Metal/element	calcium (Calcium-binding protein, Calmodulin-binding proteins) - copper (Ceruloplasmin) - iron (Iron-binding proteins, Transferrin receptor)
Vitamin	Retinol binding protein (4) - Transcobalamins
Other	Acyl carrier protein - Adaptor protein - Cholesterylester transfer protein - F-box protein - GTP-binding protein - Latent TGF-beta binding protein - Light-harvesting complex - Membrane transport protein