Protein binding motif

Protein binding motif is a short protein sequence motif that interacts with other proteins. A typical example of such motif are proline-rich sequences that are responsible for binding of SH3 domains.

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Protein binding sequences may be locally unfolded, as in many endocytic proteins. For example, some EH domains (e.g. in Eps15 protein) contain at least 15 repeats of Asp-Pro-Phe tripeptide, which are responsible for interaction with multiple copies of the AP2 alpha appendage protein.

External reading

• Schmid EM, Ford MG, Burtey A, Praefcke GJ, Peak-Chew SY, Mills IG, Benmerah A, McMahon HT. (2006) Role of the AP2 beta-Appendage Hub in Recruiting Partners for Clathrin-Coated Vesicle Assembly. PLoS Biol. Aug 15;4(9). pubmed

• Praefcke GJ, Ford MG, Schmid EM, Olesen LE, Gallop JL, Peak-Chew SY, Vallis Y, Babu MM, Mills IG, McMahon HT. (2004) Evolving nature of the AP2 alpha-appendage hub during clathrin-coated vesicle endocytosis. EMBO J. 23, 4371-83. pubmed