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Dinoprostone


Dinoprostone
Systematic (IUPAC) name
7-[3-hydroxy-2-(3-hydroxyoct-1-enyl)- 5-oxo-cyclopentyl] hept-5-enoic acid
Identifiers
CAS number	363-24-6
ATC code	G02AD02
PubChem	9691
DrugBank	APRD00927
Chemical data
Formula	C₂₀H₃₂O₅
Mol. mass	352.465 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

In medicine, dinoprostone, is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour and also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts.

Additional recommended knowledge

Daily Visual Balance Check

Essential Laboratory Skills Guide

Weighing the right way

It is sold under the trade name of Cervidil (by Forest Laboratories, Inc.), Prostin E₂ (by Pfizer Inc.) and Propess (by Ferring Pharmaceuticals), as a vaginal suppository, to prepare the cervix for labour; it is used to induce labour.

The chemical name is (5Z,11(alpha),13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1-oic acid.

Like other prostaglandins, dinoprostone can be used as an abortifacient.

It works by binding and activating the prostaglandin E2 receptor.

v • d • e Eicosanoids: prostaglandins
Endogenous/series 2	D₂ - E₂ (Dinoprostone) - H₂ - I₂ (Prostacyclin)
Prostaglandin analogues	Alprostadil - Beraprost - Bimatoprost - Carboprost - Enprostil - Iloprost - Latanoprost - Misoprostol - Travoprost - Treprostinil