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Propionyl-CoA
Propionyl-CoA is a coenzyme A derivative of propionic acid. Additional recommended knowledge
Metabolism in animalsProductionThere are several different ways in which it is formed:
Metabolic fateIn mammals, propionyl-CoA is converted to (S)-methylmalonyl-CoA by propionyl-CoA carboxylase, a biotin-dependent enzyme also requiring bicarbonate and ATP. This product is converted to (R)-methylmalonyl-CoA by methylmalonyl-CoA racemase. (R)-Methylmalonyl-CoA is converted to succinyl-CoA by methylmalonyl-CoA mutase, an enzyme requiring cobalamin to catalyze the carbon-carbon bond migration. A defect in methylmalonyl-CoA mutase enzyme results in methylmalonic aciduria, a dangerous disorder that causes a lowering of blood pH. Metabolism in plants and insectsIn plants and insects propionyl-CoA is metabolized to acetate in a very different way, similar to beta oxidation. Not all details of this pathway have been worked out, but it appears to involve formation of acrylyl-CoA, then 3-hydroxypropionyl-CoA. This is metabolized with loss of carbon 1 of 3-hydroxypropionyl-CoA as carbon dioxide, while carbon 3 becomes carbon 1 of acetate. References
Categories: Coenzymes | Metabolism |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Propionyl-CoA". A list of authors is available in Wikipedia. |