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Polymyxin B
Polymyxin B (also referred to as PMB) are antibiotics primarily used for resistant gram negative infections. Polymyxins bind to the cell membrane and alters its structure making it more permeable. The resulting water uptake leads to cell death. They are cationic, basic proteins that act like detergents. Side effects include neurotoxicity and acute renal tubular necrosis.
Additional recommended knowledgeMechanism of action
Categories: Antibiotics | Antimicrobial peptides |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Polymyxin_B". A list of authors is available in Wikipedia. |