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Plasmin
Additional recommended knowledgeFunctionsIt is a serine protease that is released as plasminogen into the circulation and activated by tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), thrombin, fibrin and factor XII (Hageman factor). It is inactived by alpha 2-antiplasmin, a serine protease inhibitor (serpin). Apart from fibrinolysis, plasmin proteolyses proteins in various other systems: it activates collagenases, some mediators of the complement system and weakens the wall of the Graafian follicle (leading to ovulation). It cleaves fibrin, fibronectin, thrombospondin, laminin and von Willebrand factor.
PathologyDeficiency in plasmin may lead to thrombosis, as clots are not degraded adequately. Further reading
Categories: Genes on chromosome 6 | Human proteins | Acute phase proteins | Fibrinolytic system | EC 3.4.21 |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Plasmin". A list of authors is available in Wikipedia. |