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Perindopril
Coversyl (perindopril) is a long-acting ACE inhibitor. International nonproprietary name: Perindopril. Additional recommended knowledge
Indications
Dosage and administrationCoversyl (perindopril) should be taken in the morning before food. For Hypertension4 mg once daily, then the dose may be increased to 8 mg after 1 month of treatment to improve blood pressure control or in case of concomitant stable coronary artery disease. In Australia, Coversyl is available as perindopril arginine. In hypertension, the initiation dose is 5 mg once daily, then the dose may be increased to 10 mg after 1 month of treatment to improve blood pressure control or in case of concomitant stable coronary artery disease. The Anglo-Scandinavian Cardiac Outcomes Trial showed the benefits of taking the two drugs Coversyl and amlodipine together. The 9000 British patients aged 40 to 79 were involved in the five-year trial. Half were given the new drug combination, the rest were given traditional drugs. Coversyl and amlodipine were found to be so effective that the trial was stopped early so that all patients could receive the combination.[1][2] For Stable coronary artery diseaseA starting dose of 4 mg for 2 weeks is recommended, then uptitration to 8 mg once daily, depending on acceptability. In Australia, Coversyl is available as perindopril arginine. A starting dose of 5 mg for 2 weeks is recommended, then uptitration to 10 mg once daily, depending on acceptability. Congestive heart diseaseCoversyl (perindopril) should be started under close medical supervision at a starting dose of 2 mg. This may be increased to 4 mg once blood pressure acceptability has been demonstrated. In Australia, Coversyl (perindopril arginine) should be started under close medical supervision at a starting dose of 2.5 mg. This may be increased to 5 mg once blood pressure acceptability has been demonstrated.
Contraindications include; children, pregnancy, lactation and situations where a patient has a history of hypersensitivity to Coversyl (perindopril). Precautions
Side effectsRare and mild, usually at the start of treatment. Cough, fatigue, asthenia, headache, disturbances of mood and/or sleep have been reported. Less often, taste impairment, epigastric discomfort, nausea, abdominal pain, and rash. Reversible increases in blood urea and creatinine may be observed. Proteinuria has occurred in some patients. Rarely, angioneurotic edema and decreases in hemoglobin, red cells, and platelets have been reported. CompositionEach tablet contains 2 mg, 4 mg or 8 mg of the tert-butylamine salt of perindopril. Perindopril is also available under the trade name Coversyl Plus®, containing 4mg of perindopril combined with 1.25mg indapamide. In Australia, each tablet contains 2.5 mg, 5 mg or 10 mg of arginine. Perindopril is also available under the trade name Coversyl Plus® and Coversyl Plus LD®, containing 5mg of perindopril combined with 1.25mg indapamide and 2.5mg of perindopril combined with 0.625mg indapamide respectively. PresentationPacks of 30 tablets of Coversyl (perindopril) 2 mg. Packs of 30 tablets of Coversyl (perindopril) 4 mg (scored). Packs of 30 tablets of Coversyl (perindopril) 8 mg. Also available under the brand names:
References
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Perindopril". A list of authors is available in Wikipedia. |