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Penitrem A
Penitrem A (tremortin) is a fungal neurotoxin found on ryegrass. It is produced by certain species of Aspergillus, Claviceps, and Penicillium. It inhibits potassium channels in smooth muscles.[citation needed] The maxi-channels targeted have their highest density in the cerebellar Purkinje cells. It causes a stagger in horses and cattle. Additional recommended knowledge
Effective doseThe ED50 for penitrem A is 10 nM.[citation needed] The ED50 is the effective dose for 50% of the population. Many toxic chemicals do not show ED-50s and act by irreversible covalent adduction. Stages of toxicitySee alsoReferences
Categories: Neurotoxins | Cell communication | Pharmacology |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Penitrem_A". A list of authors is available in Wikipedia. |