My watch list

Paracaspase

mucosa associated lymphoid tissue lymphoma translocation gene 1
Identifiers
Symbol	MALT1
Alt. Symbols	MLT
Entrez	10892
HUGO	6819
OMIM	604860
RefSeq	NM_173844
UniProt	Q9UDY8
Other data
Locus	Chr. 18 q21

Paracaspases (human: MALT1) are related to caspases present in animals and slime mold, in contrast to metacaspases which are present in plants, fungi and "protists".^[1]

Additional recommended knowledge

Correct Test Weight Handling Guide: 12 Practical Tips

Weighing the right way

How to quickly check pipettes?

Paracaspases are more similar to caspases than metacaspases are, indicating that this group of (putative) proteases diverged from caspases from a common metacaspase ancestor. The phylogenetic distribution is a bit confusing, since slime mold diverged earlier than the animal/fungal split.

References

^ Uren A, O'Rourke K, Aravind L, Pisabarro M, Seshagiri S, Koonin E, Dixit V (2000). "Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma". Mol Cell 6 (4): 961-7. PMID 11090634.

v • d • e Hydrolase: proteases (EC 3.4)
Exopeptidase 3.4.11-19	Angiotensin-converting enzyme - Dipeptidase - Dipeptidyl peptidase-4 - DD-transpeptidase Metalloexopeptidases: Aminopeptidase (Alanine, Cystinyl, Leucyl, Glutamyl) - Carboxypeptidase (A, B, C, E, Glutamate II)
Endopeptidase 3.4.21-24	Serine proteases - Cysteine protease - Aspartic acid protease - Metalloendopeptidases
Cathepsin 3.4.18,21,22,23	A - B - C - K - S