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Pancreatic hormone



Pancreatic hormone peptide
Identifiers
Symbol Hormone_3
Pfam PF00159
InterPro IPR001955
SCOP 1ppt
OPM protein 1icy
Available PDB structures:

1k8vA:1-39 1ruuA:1-36 1ru5A:1-36 1qbfA:1-36 1ron :29-64 1qfaA:52-64 1r9nF:29-38 1icyA:10-45 1f8pA:10-45 1fvnA:10-45 1ljvA:30-65 1v1dA:30-60 1bba :30-65 2bf9A:1-35 1ppt :1-36

Pancreatic hormones (PP)[1] are peptides synthesized in pancreatic islets of Langherhans, which acts as a regulator of pancreatic and gastrointestinal functions.

The hormone is produced as a larger propeptide, which is enzymatically cleaved to yield the mature active peptide: this is 36 amino acids in length[2] and has an amidated C terminus[3]. The hormone has a globular structure, residues 2-8 forming a left-handed poly-proline-II-like helix, residues 9-13 a beta turn, and 14-32 an alpha-helix,held close to the first helix by hydrophobic interactions[2]. Unlike glucagon, another peptide hormone, the structure of pancreatic peptide is preserved in aqueous solution[4]. Both N and C termini are required for activity: receptor binding and activation functions may reside in the N and C termini respectively[2].

Subfamilies

  • Pancreatic hormone subtype IPR015480
  • Peptide YY IPR015481

Human proteins containing this domain

NPY; PPY; PYY;

References

  1. ^ Humbel RE, Blundell TL (1980). "Hormone families: pancreatic hormones and homologous growth factors". Nature 287 (5785): 781-787. PMID 6107857.
  2. ^ a b c Martin J, Allen J, Novotny J, Heinrich G (1987). "Molecular structure of mammalian neuropeptide Y: analysis by molecular cloning and computer-aided comparison with crystal structure of avian homologue". Proc. Natl. Acad. Sci. U.S.A. 84 (8): 2532-2536. PMID 3031687.
  3. ^ Mutt V, Sillard R, Agerberth B, Jornvall H (1989). "Sheep neuropeptide Y. A third structural type of a highly conserved peptide". FEBS Lett. 258 (2): 263-265. PMID 2599092.
  4. ^ Conlon JM, Thim L, Bjenning C, Moon TW, Youson JH (1991). "Neuropeptide Y-related peptides from the pancreas of a teleostean (eel), holostean (bowfin) and elasmobranch (skate) fish". Peptides 12 (2): 221-226. PMID 2067973.

This article includes text from the public domain Pfam and InterPro IPR001955

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Pancreatic_hormone". A list of authors is available in Wikipedia.
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