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Posterior pituitary

Posterior pituitary

Pituitary gland. Posterior pituitary is in blue. Pars nervosa and infundibular stalk are not labeled, but pars nervosa is at bottom and infundibular stalk is at top.)

Median sagittal through the hypophysis of an adult monkey. (Posterior lobe labeled at bottom right.)
Gray's	subject #275 1275
Artery	inferior hypophyseal artery
Vein	hypophyseal vein
Precursor	Neural tube (downward-growth of the diencephalon)^[1]
MeSH	Pituitary+Gland,+Posterior
Dorlands/Elsevier	n_07/12569241

The posterior pituitary (or neurohypophysis) comprises the posterior lobe of the pituitary gland and is part of the endocrine system.

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1 Anatomy
2 Major hormones secreted
3 Role in disease
4 References
5 Additional images

Anatomy

The Posterior Pituitary Gland consists mainly of neuronal projections (axons) extending from the supraoptic and paraventricular nuclei of the hypothalamus that secrete peptide hormones into the capillaries of the hypophyseal circulation.

The neurohypophysis also contains a specialised type of astrocytic glial cell - "pituicytes".

Despite its name, the posterior pituitary gland is not a gland, per se; rather, it is largely a collection of axonal projections from the hypothalamus that terminate behind the anterior pituitary gland.

Classification of the posterior pituitary varies, but most sources include the three regions below:

Region	Description
pars nervosa, or neural lobe, or posterior lobe^[2]	This region consistutes the majority of the posterior pituitary, and is sometimes (incorrectly) considered synonymous with it. Notable features include Herring bodies and pituicytes. ^[3]
infundibular stalk	Also known as the "infundibulum" or "pituitary stalk". The term "hypothalamic-hypophyseal tract" is a near-synonym, describing the connection rather than the structure.
median eminence	This is only occasionally included as part of the posterior pituitary.^[4] Other sources specifically exclude it from the pituitary.^[5]

A few sources include the pars intermedia as part of the posterior lobe, but this is a minority view.

Major hormones secreted

Hormones known classically as posterior pituitary hormones are synthesized by the hypothalamus. They are then stored and secreted by the posterior pituitary into the bloodstream.

Hormone	Other names	Symbol(s)	Target	Effect	Source
Oxytocin	-	-	Uterus, mammary glands	Uterine contractions; lactation	paraventricular nuclei
Vasopressin	Arginine vasopressin, argipressin, antidiuretic hormone	AVP, ADH	Kidneys or Arterioles	Stimulates water retention; raises blood pressure by contracting arterioles, induces male aggression	supraoptic,

Role in disease

Insufficient secretion of vasopressin is central diabetes insipidus, in which the body loses the capacity to concentrate urine. Affected individuals excrete as much as 20 L of dilute urine per day.

Oversecretion of vasopressin causes the syndrome of inappropriate antidiuretic hormone.

References

^ Embryology at unc.edu
^ l_13/12501193 at Dorland's Medical Dictionary
^ Histology at BU 14004loa
^ n_07/12569241 at Dorland's Medical Dictionary
^ MeSH Median+eminence

Additional images

v • d • e Endocrine system > Pituitary gland
Posterior pituitary	Pars nervosa - Median eminence - Infundibular stalk
Anterior pituitary	Pars intermedia - Pars tuberalis - Pars distalis - Acidophils (Somatotropes, Lactotropes) - Basophils (Corticotropes, Gonadotropes, Thyrotropes)

v • d • e Brain: diencephalon
Epithalamus	Pineal body • Habenula (Habenular nuclei)
Hypothalamus	anterior: Anterior hypothalamic nucleus • Paraventricular nucleus • Preoptic area • Supraoptic nucleus • Suprachiasmatic nucleus intermediate/middle/tuberal/pituitary: infundibulum • median eminence • arcuate nucleus • Ventromedial nucleus • Dorsomedial hypothalamic nucleus • Tuber cinereum, Pituitary gland (Anterior pituitary, Posterior pituitary) posterior/lateral: posterior nucleus • Mammillary body • Lateral nucleus other: Medial forebrain bundle
Subthalamus	Subthalamic nucleus • Zona incerta • Thalamic fasciculus • Lenticular fasciculus
Thalamus/nuclei	Ventral nuclear group (VA/VL, VP/VPM/VPL) • MD • AN • LNG (Pulvinar) • Intralaminar nucleus (Centromedian nucleus) • Midline nuclear group • Thalamic reticular nucleus • Metathalamus (MG, LG) • Interthalamic adhesion
Third ventricle	recesses: (Optic recess, Infundibular recess, Suprapineal recess, Pineal recess) • Hypothalamic sulcus
Other	Interventricular foramina • Optic chiasm • Subfornical organ • Mammillothalamic tract

Categories: Endocrine system | Neuroendocrinology

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Posterior_pituitary". A list of authors is available in Wikipedia.