NIH funding of IBS Research
In the United States, the National Institutes of Health is the largest single entity providing funding for biomedical research. [1] In 2006 the NIH awarded 53,285 grants totalling $21 billion dollars.
[2] Irritable Bowel Syndrome (IBS) is a bowel disorder of unknown etiology characterized by abdominal pain with diarrhea and/or constipation. An estimated 15% of the US population is estimated to exhibit symptoms of IBS, with an annual medical and indirect costs estimated to range from $20 to $30 billion dollars. [3]
Additional recommended knowledge
Funding of IBS
According to the NIH's CRISP database, 1977 was the first year in which the NIH awarded a grant whose description included the phrase, "irritable bowel." [5]
A small number of grants were awarded each year through the 1970s. The graph to the right shows the number of researchers receiving NIH grant awards for grants including the term "irritable bowel" for years 1974 to 2007. [6]
Recent Funding
In 2006, the NIH funded 56 projects [7] focusing on Irritable Bowel Syndrome, with a total disbursement of $18,787,710. [8]
Supporting Data
| List of NIH Funded Research Projects Referring to 'Irritable Bowel' for 2006 [7] [8]
|
| Project Number
| Project Title
| Dollars Awarded
| Institution
| State
|
| 5R24DK067674-03
| Gastrointestinal Biopsychosocial Research Center
| 854,134
| University of North Carolina
| NC
|
| 3R24DK067674-03S1
| Gastrointestinal Biopsychosocial Research Center
| 146,292
| University of North Carolina
| NC
|
| 1K23DK073451-01
| Central and Peripheral Autonomic Responses in IBS
| 125,010
| UCLA
| CA
|
| 5K24DK002638-08
| Alpha 2 Adrenergic Control in Irritable Bowel Syndrome
| 139,598
| MAYO CLINIC
| MN
|
| 1R21AT003619-01
| Mindfulness for Irritable Bowel Syndrome
| 219,000
| University of North Carolina
| NC
|
| 5R01AT001414-04
| Enhancing the Placebo Effect in Irritable Bowel Syndrome
| 642,916
| Harvard
| MA
|
| 5R01NR007768-05
| Treatment of Fear and Pain in Irritable Bowel Syndrome
| 299,479
| BRENTWOOD
| CA
|
| 5K23DK066271-03
| Genetic epidemiology of irritable bowel syndrome (IBS)
| 126,900
| MAYO CLINIC
| MN
|
| 5R21AT002564-02
| Patient Variables and Placebo Responses in IBS
| 193,460
| MASSACHESSES GENERAL HOSPIAL
| MA
|
| 5R21DK069628-02
| Cross-sensitization between the bladder and colon
| 144,131
| VIRGINIA COMMONWEALTH UNIVERSITY
| VA
|
| 5U19AT003266-02
| Functional Bowel Disorders in Chinese Medicine
| 1,007,873
| UNIVERSITY OF MARYLAND
| MD
|
| 5R21DK071767-02
| Regulation of spinal NK1R expression by chronic stress
| 153,798
| BRENTWOOD
| CA
|
| 5R01DK054681-07
| Alpha-2 Adrenergic Control of Colonic Function in IBS
| 235,240
| MAYO CLINIC
| MN
|
| 2R01NR001094-17A2
| A Nursing Study of Gut Function in Menstruating Women
| 522,661
| UNIVERSITY OF WASHINGTON
| WA
|
| 5R03NR009410-02
| Autonomic nervous system and visceral hypersensitivity
| 74,019
| UNIVERSITY OF WASHINGTON
| WA
|
| 1K08DK071626-01A1
| Effective connectivity of central response to IBS
| 121,538
| UNIVERSITY OF CALIFORNIA
| CA
|
| 5K23NS043435-05
| Spatial and Temporal Characteristics of Central Pain Se
| 164,990
| UNIVERSITY OF FLORIDA
| FL
|
| 5P50DK064539-05
| Women's Health and Functional Visceral Disorders Center
| 1,133,615
| UCLA
| CA
|
| 5R21DK068155-02
| CRF2 Receptor Modulation of Colonic Response to Stress
| 184,559
| UCLA
| CA
|
| 5R01DK066658-04
| Neurogenic Pathogenesis of Interstitial Cystitis
| 305,824
| UNIVERSITY OF PITTSBURGH
| PA
|
| 1F31DK074378-01A1
| Minority Predoctoral Fellowship Program
| 26,728
| PONCE SCHOOL OF MEDICINE
| PR
|
| 5R01NR005337-05
| Recurrent Abdominal Pain in Children
| 443,225
| BAYLOR COLLEGE
| TX
|
| 5R01DK062768-02
| Effects of Short Chain Fatty Acids on Colonic Motility
| 227,581
| DUKE
| NC
|
| 5R01NS037424-07
| Neurochemical Mechanisms of Visceral Pain
| 344,400
| UNIVERSITY OF MD
| MD
|
| 5R01NS053090-02
| Mechanisms of Central and Peripheral Hyperalgesia
| 328,562
| UNIVERSITY OF FLORIDA
| FL
|
| 5R01NS044222-03
| Medial Pain Inputs to Monkey Anterior Cingulate Cortex
| 274,593
| UPSTATE MEDICAL UNIVERSITY
| NY
|
| 5R01DK064880-04
| A Case Control Study of Interstitial Cystitis
| 524,437
| UNIVERSITY OF MD
| MD
|
| 5K08DK060468-04
| GDNF in the Enteric Nervous System
| 130,113
| OHIO STATE UNIVERSITY
| OH
|
| 1R15GM073620-01A1
| STRUCTURE FUNCTION STUDY OF MT3 TOXIN
| 185,220
| UNIVERSITE CENTRAL
| PR
|
| 5K24AT000057-08
| Individual Differences in CAM Patient-Centered Outcomes
| 156,399
| UNIVERSITY OF AZ
| AZ
|
| 2R01AR046122-06A1
| Neuroendocrine Alterations in Fibromyalgia and IBS
| 277,200
| UCLA
| CA
|
| 5F32DK071430-02
| Bacterial regulation of GI tract cell proliferation
| 48,796
| UNIVERSITY OF OREGON
| OR
|
| 5R01NS050758-02
| Characterization and Plasticity of Visceral Nociceptors
| 328,232
| UNIVERSITY OF PITTSBURGH
| PA
|
| 5R03DE015814-02
| Central role of JNK/Jun cascade in visceral nociception
| 73,726
| UNIVERSITY OF TEXAS
| TX
|
| 5R01NS019912-25
| Mechanisms and Modulation of Visceral Pain
| 369,355
| UNIVERSITY OF PITTBURGH
| PA
|
| 5P50AR049555-05
| ORWH: SCOR on Sex and Gender Factors Affecting Women's *
| 1,073,218
| UNIVERSITY OF MD
| MD
|
| 5R01NR004142-09
| Nursing Management of IBS: Improving Outcomes
| 595,794
| UNIVERSITY OF WASHINGTON
| WA
|
| 2R01DK057038-06A2
| RET Ligand Regulation of Intestinal Motility
| 250,100
| WASHINGTON UNIVERSITY
| MO
|
| 5R01DK064592-04
| Neuronal control of intestinal motility in mutant mice
| 488,250
| WASHINGTON UNIVERSITY
| MO
|
| 5R01DK047700-11
| Regulation of immunosuppressive molecules in IBD
| 213,944
| UNIVERSITY OF NORTH CAROLINA
| NC
|
| 1R01DA019824-01A1
| Role of cannabinoid 2 receptors in B lymphocyte function
| 290,000
| UNIVERSITY OF SOUTH FLORIDA
| FL
|
| 1R01NS051466-01A1
| ACC Sensitization in Visceral Hypersensitive Rats
| 342,029
| UNIVERSITY OF MICHIGAN
| MI
|
| 2R01DK058173-06A1
| Peripheral NMDA Receptors in Visceral Nociception
| 305,553
| UCLA
| CA
|
| 1R21AT003221-01A1
| Physiologic Characteristics of Traditional Chinese Medicine Based IBS Subgroups
| 193,125
| UCLA
| CA
|
| 5R21DK069933-02
| Oxalobacter as a therapy in IBD-associated urolithiasis
| 213,121
| UNIVERSITY OF FLORIDA
| FL
|
| 5R01DK056762-06
| Role of IL-18 in Crohn's Disease (CD)
| 292,921
| UNIVERSITY OF VIRGINIA
| VA
|
| 5R01MH072908-02
| Stress Allostasis: CRF, Serotonin and the BNST
| 310,936
| EMORY UNIVERSITY
| GA
|
| 5R01DK041004-17
| Cholecystokinin--Role in Postprandial Gastric Motility
| 293,069
| UC/DAVIS
| CA
|
| 1K23DK075621-01
| The Role of Intestinal Inflammation in the Pathophysiology of IBS
| 157,184
| UNIVERSITY OF NORTH CAROLINA
| NC
|
| 5R01AT001424-04
| BRAIN IMAGING AND PAIN: ANALYSIS OF PLACEBO ANALGESIA
| 308,305
| UNIVERSITY OF FLORIDA
| FL
|
| 5P30DK034987-21
| CENTER FOR GASTROINTESTINAL BIOLOGY AND DISEASE
| 998,793
| UNIVERSITY OF NORTH CAROLINA
| NC
|
| 5R01NS038767-06
| Mechanism of Pain in Patients with Fibromyalgia Syndrome
| 324,863
| UNIVERSITY OF FLORIDA
| FL
|
| 5R01DK033061-22
| Corticotropin-releasing Factor-action on GI Function
| 271,071
| UCLA
| LA
|
| 1R21AA016701-01
| Mast cells, antidepressants and chronic fatigue syndrome
| 275,906
| TUFFTS
| MA
|
| 5R01DK038327-19
| Substance P & the Regulation of Intestinal Inflammation
| 340,541
| NEW ENGLAND MEDICAL CTR
| MA
|
| 5R01DK031369-19
| Psychophysiology of Irritable Bowel Synbdrome
| 423,409
| UNIVERSITY OF NORT CAROLINA
| NC
|
| 5R01DK068258-03
| PURINERGIC NEUROGENIC MUCOSAL SECRETION
| 291,974
| OHIO STATE UNIVERSITY
| OH
|
| Total
|
| 18,787,710
|
|
|
References
- ^ Medical Research Spending Doubled Over Past Decade, Neil Osterweil, MedPage Today, September 20, 2005.
- ^ TAGGS FY 2006 Annual Report. Retrieved on September 8, 2007.
- ^ {{Hulisz D. (2004). "The burden of illness of irritable bowel syndrome: current challenges and hope for the future.". J Manag Care Pharm. 10 (4): 299-309. PMID 15298528.
- ^ NIH CRISP Search Tool, search for phrase Irritable Bowel. Retrieved on September 8, 2007.
- ^ NIH CRISP Search Tool, search for phrase Irritable Bowel. Retrieved on September 8, 2007.
- ^ NIH CRISP Search Tool, phrase search for Irritable Bowel for individual years. Retrieved on September 8, 2007.
- ^ a b NIH CRISP Search Tool, phrase search for Irritable Bowel for year 2006. Retrieved on September 8, 2007.
- ^ a b NIH Award Database. Retrieved on September 8, 2007.
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