Mesoridazine

Mesoridazine besylate (sold as Serentil) is a piperidine antipsychotic neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia, organic brain disorders, psychoneuroses, and alcoholism. It is the besylate salt of a metabolite of thioridazine. Serious side effects include akathisia, tardive dyskinesia and the potentially fatal neuroleptic malignant syndrome. It exerts its actions through blockade of central adrenergic receptors, dopamine receptors, serotonin receptors, and an anticholinergic blocking.^[1] It also exerts part of its actions through depression of hypothalamic centers, like other phenothiazines.

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Mesoridazine partially derives its name from the prefix "Meso"^{[citation needed]} which means "middle" which is the center of the brain called the limbic system where most dopaminergic activity takes place. The middle of the brain also contains the pineal gland and hypothalamus.

For further information see: Phenothiazine

Mesoridazine was withdrawn from the United States market in 2004.

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