Membranoproliferative glomerulonephritis

**Membranoproliferative glomerulonephritis**
*Classification & external resources*
ICD-10	N00-N08 with .2 suffix
ICD-9	581.2, 582.2, 583.2
MeSH	D015432

Membranoproliferative glomerulonephritis or MPGN is a type of glomerulonephritis caused by immune complexes depositing in the kidney glomerular mesangium and basement membrane (GBM), activating complement and damaging the glomeruli. The GBM is rebuilt ontop of the deposits, causing a "tram-tracking" appearance under the microscope.

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Type

There are three types of MPGN.

The most common by far is Type I, described above.
Type II (dense deposit disease) is very similar, except the material deposited is not immune complexes and is not yet known.
Type III is very rare, it is characterized by a mixture of subepithelial deposits and the typical pathological findings of Type I disease.

v • d • e Urinary system - Pathology - Nephrology (N00-N39, 580-599)
Diseases of the glomerulus	Glomerulonephritis - Focal segmental glomerulosclerosis - Membranoproliferative glomerulonephritis - Membranous glomerulonephritis - Nephritic syndrome - Post-streptococcal glomerulonephritis - Nephrotic syndrome (Minimal change disease) - IgA nephropathy - Lupus nephritis - Diabetic nephropathy - Rapidly progressive glomerulonephritis
Tubulointerstitial diseases of the kidney	Interstitial nephritis - Pyelonephritis - Hydronephrosis - Pyonephrosis - Balkan nephropathy - Reflux nephropathy
Renal failure	Acute renal failure (Acute tubular necrosis) - Chronic renal failure
Urolithiasis	Kidney stone - Renal colic
Diseases of the renal tubule and other disorders of kidney and ureter	Renal osteodystrophy - Nephrogenic diabetes insipidus - Renal tubular acidosis - Nephroptosis - Ureterocele
Other diseases and disorders of urinary system	urinary bladder: Cystitis (Interstitial cystitis, Trigonitis) - Neurogenic bladder - Vesicointestinal fistula urethra: Urethritis (Non-gonococcal urethritis) - Urethral syndrome - Urethral stricture Urinary tract infection
Tumors of the kidney	Renal cell carcinoma - Wilms' tumor (children)
See also congenital conditions (Q60-Q64, 753)