Cannabis (drug)

Cannabis, also known as marijuana^[1] or ganja (Hindi: गांजा gānjā),^[2] is a psychoactive product of the plant Cannabis sativa. The herbal form of the drug consists of dried mature flowers and subtending leaves of pistillate ("female") plants. The resinous form, known as hashish,^[3] consists primarily of glandular trichomes collected from the same plant material.  The major biologically active chemical compound in cannabis is Δ⁹-tetrahydrocannabinol (delta-9-tetrahydrocannabinol), commonly referred to as THC.

Humans have been consuming cannabis since prehistory,^[4] although in the 20th century there was a rise in its use for recreational, religious or spiritual, and medicinal purposes. It is estimated that about four percent of the world's adult population use cannabis annually and 0.6 percent daily.^[5] The possession, use, or sale of psychoactive cannabis products became illegal in most parts of the world in the early 20th century. Since then, some countries have intensified the enforcement of cannabis prohibition while others have reduced the priority of enforcement.

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History

Evidence of the inhalation of cannabis smoke can be found as far back as the Neolithic age, as indicated by charred cannabis seeds found in a ritual brazier at an ancient burial site in present day Romania.^[4] The most famous users of cannabis were the ancient Hindus of India and Nepal, and the Hashshashins (hashish eaters) of present day Syria. The herb was called ganjika in Sanskrit (गांजा/গাঁজা ganja in modern Indic languages).^[6][7] The ancient drug soma, mentioned in the Vedas as a sacred intoxicating hallucinogen, was sometimes associated with cannabis.^[8]

Cannabis was also known to the Assyrians, who discovered its psychoactive properties through the Aryans.^[9] Using it in some religious ceremonies, they called it qunubu (meaning "way to produce smoke"), a probable origin of the modern word 'Cannabis'.^[10] Cannabis was also introduced by the Aryans to the Scythians and Thracians/Dacians, whose shamans (the kapnobatai—“those who walk on smoke/clouds”) burned cannabis flowers to induce a state of trance.^[11] Members of the cult of Dionysus, believed to have originated in Thrace, are also thought to have inhaled cannabis smoke. In 2003, a leather basket filled with cannabis leaf fragments and seeds was found next to a 2,500- to 2,800-year-old mummified shaman in the northwestern Xinjiang Uygur Autonomous Region of China.^[12][13]

Cannabis has an ancient history of ritual use and is found in pharmacological cults around the world. Hemp seeds discovered by archaeologists at Pazyryk suggest early ceremonial practices like eating by the Scythians occurred during the 5th to 2nd century BCE, confirming previous historical reports by Herodotus.^[14] Some historians and etymologists have claimed that cannabis was used as a religious sacrament by ancient Jews and early Christians.^[15] It was also used by Muslims in various Sufi orders as early as the Mamluk period, for example by the Qalandars.^[16] In India and Nepal, it has been used by some of the wandering spiritual sadhus for centuries, and in modern times the Rastafari movement has embraced it as a sacrament.^[17] Elders of the modern religious movement known as the Ethiopian Zion Coptic Church consider cannabis to be the Eucharist, claiming it as an oral tradition from Ethiopia dating back to the time of Christ, even though the movement was founded in the United States in 1975 and has no ties to either Ethiopia or the Coptic Church.^[18] Like the Rastafari, some modern Gnostic Christian sects have asserted that cannabis is the Tree of Life.^[19][20] Other organized religions founded in the past century that treat cannabis as a sacrament are the THC Ministry,^[21] the Way of Infinite Harmony, Cantheism,^[22] the Cannabis Assembly^[23] and the Church of Cognizance.

Cannabis was introduced to the Americas in the mid-19th century by Indian laborers under the Indian indenture system implemented by the British Empire after the end of African slavery in the British West Indies. In the Caribbean, cannabis is still known as ganja (the Sanskrit word for marijuana), Indian or Coolie weed. The plant eventually spread into Mexico, U.S., Canada and the rest of the Americas.^{[citation needed]}

The production of cannabis for drug use remains illegal throughout most of the world through for ex. International Opium Convention of 1925, the Marijuana Tax Act of 1937, the 1961 Single Convention on Narcotic Drugs, the 1971 Convention on Psychotropic Substances, and the 1988 United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances, while simple possession of small quantities is either legal, or treated as an addiction rather than a criminal offense in a few countries.

Medical use

Main article: Medical cannabis

A synthetic form of one chemical in marijuana, Delta-9 Tetrahydrocannabinol (THC), is a controversial treatment for medical use. The American Marijuana Policy Project, a pro-cannabis organization, claims that cannabis is an ideal therapeutic drug for cancer and AIDS patients, who often suffer from clinical depression, and from nausea and resulting weight loss due to chemotherapy and other aggressive treatments. A recent study by scientists in Italy has also shown that cannabidiol (CBD), a chemical found in marijuana, inhibits growth of cancer cells in animals.^[24]

FDA and comparable authorities in Western Europe, including the Netherlands, have not approved smoked marijuana for any condition or disease. The current view of the United States Food and Drug Administration is that if there is any future of marijuana as a medicine, it lies in its isolated components, the cannabinoids and their synthetic derivatives.^[25]

A synthetic extract of cannabis has been shown to relieve symptoms of anorexia in elderly Alzheimer's patients.^[26]

Glaucoma, a condition of increased pressure within the eyeball causing gradual loss of sight, can be treated with medical marijuana to decrease this intraocular pressure. There has been debate for 25 years on the subject. Some data exist, showing a reduction of IOP in glaucoma patients who smoke marijuana,^[27] but the effects are short-lived, and the frequency of doses needed to sustain a decreased IOP can cause systemic toxicity. There is also some concern over its use since it can also decrease blood flow to the optic nerve. Marijuana lowers IOP by acting on a cannabinoid receptor on the ciliary body called the CB receptor.^[28] Although marijuana is not a good therapeutic choice for glaucoma patients, it may lead researchers to more effective, safer treatments. A promising study shows that agents targeted to ocular CB receptors can reduce IOP in glaucoma patients who have failed other therapies.^[29]

Medical marijuana is used for analgesia, or pain relief. “Marijuana is used for analgesia only in the context of a handful of illnesses (e.g., headache, dysentery, menstrual cramps, and depression) that are often cited by marijuana advocates as medical reasons to justify the drug being available as a prescription medication.”^[30] It is also reported to be beneficial for treating certain neurological illnesses such as epilepsy, and bipolar disorder.^[31] Case reports have found that cannabis can relieve tics in people with obsessive compulsive disorder and Tourette syndrome. Patients treated with tetrahydrocannabinol, the main psychoactive chemical found in cannabis, reported a significant decrease in both motor and vocal tics, some of 50% or more.^[32][33][34] Some decrease in obsessive-compulsive behavior was also found.^[32] A recent study has also concluded that cannabinoids found in cannabis might have the ability to prevent Alzheimer's disease.^[35] THC has been shown to reduce arterial blockages.^[36]

Another use for medical marijuana is movement disorders. Marijuana is frequently reported to reduce the muscle spasms associated with multiple sclerosis; this has been acknowledged by the Institute Of Medicine, but it noted that these abundant anecdotal reports are not well-supported by clinical data. Evidence from animal studies suggests that there is a possible role for cannabinoids in the treatment of certain types of epileptic seizures.^[37] Marijuana "numbs" the nervous system slightly, possibly preventing shock. A synthetic version of the major active compound in cannabis, THC, is available in capsule form as the prescription drug dronabinol (Marinol) in many countries. The prescription drug Sativex, an extract of cannabis administered as a sublingual spray, has been approved in Canada for the treatment of multiple sclerosis.^[38] Dr. William Notcutt states that the use of MS as the disease to study “had everything to do with politics”.^[39]

New breeding and cultivation techniques

Main article: Cannabis (drug) cultivation

It is often claimed by growers and breeders of herbal cannabis that advances in breeding and cultivation techniques have increased the potency of cannabis since the late 1960s and early '70s, when delta-9-tetrahydrocannabinol was discovered and understood. However, potent seedless marijuana such as "Thai sticks" were already available at that time. In fact, the sinsemilla technique of producing high-potency marijuana has been practiced in India for centuries. Sinsemilla (Spanish for "without seed") is the dried, seedless inflorescences of female cannabis plants. Because THC production drops off once pollination occurs, the male plants (which produce little THC themselves) are eliminated before they shed pollen to prevent pollination. Advanced cultivation techniques such as hydroponics, cloning, high-intensity artificial lighting, and the sea of green method are frequently employed as a response (in part) to prohibition enforcement efforts that make outdoor cultivation more risky. These intensive horticultural techniques have led to fewer seeds being present in cannabis and a general increase in potency over the past 20 years. The average levels of THC in marijuana sold in United States rose from 3.5% in 1988 to 7% in 2003 and 8.5% in 2006.^[40]

"Skunk" cannabis is a potent strain of cannabis, grown through selective breeding and usually hydroponics, that is a cross-breed of Cannabis sativa and C. indica. Skunk cannabis potency ranges usually from 6% to 15% and rarely as high as 20%. The average THC level in coffeehouses in the Netherlands is about 18–19%.^[41]

The average THC content of Skunk #1 is 8.2%; it is a 4-way combination of the cannabis strains Afghani indica, Mexican Gold, Colombian Gold, and Thai: 75% sativa, 25% indica. This was done via extensive breeding by cultivators in California in the 1970s using the traditional outdoor cropping methods used for centuries.

In proposed revisions to cannabis rescheduling in the UK, the government is considering scheduling the more potent cannabis material as a separate, more restricted substance. Many cannabis proponents are vehemently opposed, reasoning that if one can smoke less cannabis to achieve the same effect, then it is safer in the long run than smoking a less potent product.

A Dutch double-blind, randomized, placebo-controlled, cross-over study of male volunteers with a self-reported history of regular cannabis use aged 18–45 years concluded that smoking of cannabis, with higher THC reflecting the content levels of netherweed (marijuana with 9–23% THC) as currently sold in coffee shops in the Netherlands, may lead to higher THC concentrations in serum (the internal dose). Smoking of cannabis with higher THC concentrations leads to an increase of the occurrence of effects, particularly among younger or inexperienced cannabis smokers, who do not adapt their smoking to the higher THC.^[42] Smoking of cannabis with higher THC concentrations was associated with a dose-related increase of physical effects (such as increase of heart rate, and decrease of blood pressure) and psychomotor effects (such as reacting more slowly, being less concentrated, making more mistakes during performance testing, having less motor control, and experiencing drowsiness).

What was well observed in the Dutch study was that the effects based from a single dose—the smoking of one piece of a joint for 20–25 minutes—lasted for more than eight hours. The reaction time was still significantly slower about five hours after smoking. At that time, the THC serum concentration was low, but still present. This means that even when individuals have the impression that their state has returned to baseline and that they can smoke another piece of joint, the effect of the first joint may be still present. When subjects smoke on several occasions per day, accumulation of THC may occur.

Another study showed that 15 mg THC result in no learning whatsoever occurring over a three-trial selective reminding task at two hours. In several tasks, delta(9)-THC increased both speed and error rates, reflecting “riskier” speed–accuracy trade-offs.^[43]

There are two recognized types of herbal cannabis, sativa and indica. So-called sativa strains are reputed to induce a noticeably more "cerebral" high, while indica strains induce more of a body high. These two drug types are often hybridized or crossed with early-maturing (but low in THC) ruderalis strains to increase the range in desirable characteristics.

Criminalization and legalization

Main article: Legality of cannabis

See also: Drug prohibition and Drug liberalization

Since the beginning of the 20th century, most countries have enacted laws against the cultivation, possession, or transfer of cannabis for recreational use. These laws have impacted adversely on the cannabis plant's cultivation for non-recreational purposes, but there are many regions where, under certain circumstances, handling of cannabis is legal or licensed. Many jurisdictions have lessened the penalties for possession of small quantities of cannabis, so that it is punished by confiscation or a fine, rather than imprisonment, focusing more on those who traffic the drug on the black market. There are also changes in a more restrictive direction such as the closing of coffee shops in the Netherlands, the closing of the open drug market in Christiania, Copenhagen and the higher minimum penalties as in Canada. Although recently in Canada the use of marijuana has been decriminalized and laws in certain provinces (such as British Columbia) have been un-enforced. Some jurisdictions use mandatory treatment programs for frequent known users with freedom from narcotic drugs as goal. Simple possession can carry long prison terms in some countries, particularly in East Asia, where the sale of cannabis may lead to a sentence of life in prison or even execution.

Effects

Main article: Health issues and the effects of cannabis

Cannabis has psychoactive and physiological effects when consumed, usually by smoking or ingestion. The minimum amount of THC required to have a perceptible psychoactive effect is about 10 micrograms per kilogram of body weight^[44] (which, in practical terms, is a varying amount, dependent upon potency). A related compound, Δ⁹-tetrahydrocannabivarin, also known as THCV, is produced in appreciable amounts by certain drug strains. This cannabinoid has been described in the popular literature as having shorter-acting, flashier effects than THC, but recent studies suggest that it may actually inhibit the effects of THC. Relatively high levels of THCV are common in African dagga (marijuana), and in hashish from the northwest Himalayas.

Health issues

Main article: Health issues and the effects of cannabis

Cannabis use has been shown to be associated with several illnesses. Whilst some studies and tests have proven inconclusive,^{[citation needed][45]}a recent study by the Canadian government found cannabis contained more toxic substances than tobacco smoke. It contained 20 times more ammonia, (a carcinogen) and five times more of hydrogen cyanide (which can cause heart disease) and of nitrogen oxides, (which can cause lung damage) than tobacco smoke.^[46] Cannabis use has been linked to psychosis by several peer-reviewed studies. A 1987 Swedish study claiming a link between cannabis use and schizophrenia was criticized for not differentiating between cannabis use and the use of other narcotics, and its results have not been verified by other studies. More recently, the Dunedin Multidisciplinary Health and Development Study published research showing an increased risk of psychosis for cannabis users with a certain genetic predisposition, held by 25% of the population.^[47] In 2007, a study published in The Lancet and a poll of mental health experts showed that a growing number of medical health practitioners are convinced that cannabis use increases susceptibility to mental illness, accounting for 14% of United Kingdom psychosis cases; however, the risk to an individual smoking cannabis is only increased by 2%.^[48]

Although long terms effects of cannabis use is polarised in the scientific community preventing any firm consensus of its effects, short term effects are well documented. Effects such as short-term memory and attention loss, loss of motor skills and dexterity, reduced reaction time, and lower abilities to perform skilled activities can be hazardous to human life if combined with potentially hazardous activities such as driving. Cannabis use can also lead to anxiety and panic reactions. There is also evidence that some of the above effect can become permanent with heavy usage ^[49]

Multiple studies have shown that chronic heavy cannabis smoking is associated with increased symptoms of chronic bronchitis, such as coughing, production of sputum, and wheezing. Lung function is also significantly poorer and there is a significantly greater amount of abnormalities in the large airways of marijuana smokers than in non-smokers.^{[50] [51][52]}.

All of these health issues can potentially be exacerbated by a cannabis dependence syndrome ^[53].

Relationship with other drugs

Since its origin in the 1950s, the "gateway drug" hypothesis has been one of the central pillars of cannabis drug policy in the United States. The argument is that people, upon trying cannabis for the first time and not finding it dangerous, are then tempted to try other, harder drugs. This model of cause and effect has been debated.^[54] Some argue that the purported relationship between marijuana and more illicit drugs, as proposed by the "gateway theory," is methodologically flawed. A common argument is that a new user of cannabis who doesn't find it dangerous will see the difference between public information regarding the drug and their own experiences, and apply this distrust to public knowledge of other, more powerful drugs. Some studies support the "gateway drug" model.^[55] An example from 2007: A stratified, random sample of 1943 adolescents was recruited from secondary schools across Victoria, Australia, at age 14–15 years. This cohort was interviewed on eight occasions until the age of 24–25 years. At age 24 years, 12% of the sample had used amphetamines in the past year, with 1–2% using at least weekly. Young adult amphetamine use was predicted strongly by adolescent drug use and was associated robustly with other drug use and dependence in young adulthood. Associations were stronger for more frequent users. Among young adults who had not been using amphetamines at age 20 years, the strongest predictor of use at age 24 years was the use of other drugs, particularly cannabis, at 20 years.^[56] Those who were smoking cannabis at the age of 15 were as much as 15 times more likely to be using amphetamines in their early 20s.^[57]

Analysts have hypothesized that the illegal status of cannabis is a possible cause of a gateway drug effect, reasoning that cannabis users are likely to become acquainted with people who use and sell other illegal drugs in order to acquire cannabis. But it is said to be that Marijuana is not as harmful or addicting as any other drug.^[58][59] Some contend that by this argument, alcohol and tobacco may also be regarded as gateway drugs. Studies have shown that tobacco smoking is a better predictor of concurrent illicit hard drug use than smoking cannabis.^[60] 

A current doctoral thesis from Karolinska Institutet, Stockholm, on the neurobiological effects of early life cannabis exposure, gives support for the cannabis gateway hypothesis in relation to adult opiate abuse. THC exposed rats showed increased motivation for opiate drug use under conditions of stress. However, the cannabis exposure did not correlate to amphetamine use.^[61]

A study^[62] published in The Lancet on 24 March 2007 was twenty drugs were assigned a risk from zero to three. Dr. David Nutt et al. asked medical, scientific and legal experts to rate 20 different drugs on nine parameters:

• Physical harm (Acute, Chronic, and Intravenous harm)
• Dependence (Intensity of pleasure, Psychological dependence, Physical dependence)
• Social harms (Intoxication, Other social harms, Health-care costs)

Cannabis was ranked seventeenth of twenty for mean physical harm score and eleventh for mean dependence score. Not shown is the mean social harm score, which rated ninth, in a tie with Amphetamine.

Poly drug use is not unusual among established user's; statistics from for ex Spain show that cannabis user's age 15 -34 also used amphetamine (9%), ecstasy (11%) or cocaine (18%) the same year.^[63] Aggression and violent outbursts can occur with benzodiazepines when they are combined with cannabis.

Classification

While many drugs clearly fall into the category of either Stimulant, Depressant, Hallucinogen, or Antipsychotic, cannabis, containing both THC and CBD, exhibits a mix of all sections, leaning towards the Hallucinogen section due to THC being the primary constituent.^[64][65][66]

Methods of consumption

Cannabis is prepared for human consumption in several forms:

• Marijuana or ganja: the flowering tops of female plants, from less than 1% THC to 22% THC; the wide range is probably one of the reasons for the conflicting results from different studies.
• Hashish or charas: a concentrated resin composed of heated glandular trichomes that have been physically extracted, usually by rubbing, sifting, or with ice.
• Kief: (1) the chopped flowering tops of female cannabis plants, often mixed with tobacco; (2) Moroccan hashish produced in the Rif mountains;^[67] (3) sifted cannabis trichomes consisting of only the glandular "heads" (often incorrectly referred to as "crystals" or "pollen"); (4) the crystal (trichomes) left at the bottom of a grinder after grinding marijuana, then smoked.
• Bhang: a beverage prepared by grinding cannabis leaves in milk and boiling with spices and other ingredients.

These forms are not exclusive, and mixtures of two or more different forms of cannabis are frequently consumed. Between the many different strains of cannabis and the various ways that it is prepared, there are innumerable variations similar to the wide variety of mixed alcoholic beverages that are consumed.

Smoking

Main article: Cannabis smoking

Cannabis can be smoked in a variety of ways, some of which are more popular than others. The most common methods of smoking cannabis involve the use of implements such as bongs and smoking pipes, or rolling joints or blunts[2]. These methods differ by: the preparation of the cannabis plant before use; the parts of the cannabis plant which is used; and the treatment of the smoke before inhalation.

Vaporization

A vaporizer heats herbal cannabis to 365–410 °F (185–210 °C), which turns the active ingredients into gas without burning the plant material (the boiling point of THC is 392 °F (200°C) at 0.02 mm Hg pressure, and somewhat higher at standard atmospheric pressure).^[68][69] Toxic chemicals are released at much lower levels than by smoking, although this may vary depending on the design of the vaporizer and the temperature at which it is set. A MAPS-NORML study using a Volcano vaporizer reported 95% THC and no toxins delivered in the vapor.^[70] However, an older study using less sophisticated vaporizers found more toxins.^[71] The effects from a vaporizer are noticeably different to that of smoking cannabis. Users have reported a more euphoric hallucinogen type high, because the vapor contains more pure THC.

Eating

As an alternative to smoking, cannabis may be consumed orally. Although hashish is sometimes eaten raw or mixed with water, THC and other cannabinoids are more efficiently absorbed into the bloodstream when dissolved in ethanol, or combined with butter or other lipids. The time to onset of effects is usually about an hour and may continue for a considerable length of time, whereas the effects of smoking herbal cannabis are almost immediate.

Smoking cannabis results in a significant loss of THC and other cannabinoids in the exhaled smoke, by decomposition on burning, and in smoke that is not inhaled. In contrast, all of the active constituents enter the body when cannabis is ingested. It has been shown that the primary active component of cannabis, Δ9-THC, is converted to the more psychoactive 11-hydroxy-THC by the liver.^[72] Titration to the desired effect by ingestion is much more difficult than through inhalation.

Other methods

Cannabis material can be leached in high-proof spirits (often grain alcohol) to create “Green Dragon”. This process is often employed to make use of low-potency stems and leaves.

Cannabis can also be consumed as a tea. Although THC is lipophilic and only slightly water soluble (with a solubility of 2.8 grams per liter^[73]), enough THC can be dissolved to make a mildly psychoactive tea. However, water-based infusions are generally considered to be an inefficient use of the herb.

In 2006, hollowed-out gumballs filled with cannabis material and labeled as “Greenades” were distributed by high school students in the U.S.^[74]

See also

References

• [4] Marijuana Tax Act of 1937

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