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Malic acid
Malic acid is a tart-tasting organic dicarboxylic acid that plays a role in many sour or tart foods. The salts and esters of malic acid are known as malates. Malate anion is an intermediate in the citric acid cycle along with fumarate. It can also be formed from pyruvate as one of the anaplerotic reactions. Additional recommended knowledge
HistoryMalic acid was first isolated from apple juice by Carl Wilhelm Scheele in 1785. Antoine Lavoisier in 1787 proposed the name acide malique which is derived from the latin word for apple, malum.[1] BiologyMalate is an important chemical compound in biochemistry. In biological sources, malic acid is homochiral and only exists as the (-)-malic acid enantiomer. In the C4 carbon fixation process, malate is a source of CO2 in the Calvin cycle. In the citric acid cycle, (S)-malate is an intermediate formed by the addition of an -OH group on the si face of fumarate; it can also be formed from pyruvate via anaplerotic reactions. Malate dehydrogenase catalyzes the reversible conversion of malate into oxaloacetate using NAD as a cofactor. Malate is also produced from starch in guard cells of plant leaves. A build up of malate leads to a low water potential. Water then flows into the guard cells causing the stoma to open. However, this process does not always induce the opening of stomas. Apples contain malic acid, which contributes to the sourness of a green apple. Malic acid can make a wine taste tart, although the amount decreases with increasing fruit ripeness. The process of malolactic fermentation converts malic acid to much milder lactic acid. As a food additiveMalic acid, when added to food products, is denoted by E number E296. Malic acid is the source of extreme tartness in so called "extreme candy", for example Mega Warheads. It is also used with or in place of the less sour citric acid in sour candies such as Jolly Ranchers, SweeTarts and Jimmy Johns Salt & Vinegar potato chips. These candies are sometimes labeled with a warning that excessive consumption can cause irritation of the mouth. ChemistryMalic acid stars in the discovery of the Walden inversion and the Walden cycle in which (-)-malic acid first is converted into (+)-chlorosuccinic acid by action of phosphorus pentachloride. Wet silver oxide then takes the chlorine compound to (+)-malic acid which then reacts with PCl5 to the (-)-chlorosuccinic acid. The cycle is completed when silver oxide takes this compound back to (-)-malic acid. Self-condensation of malic acid with fuming sulfuric acid gives the pyrone coumalic acid:[2] See also
References
Categories: Citric acid cycle | Cellular respiration | Citric acid cycle compounds |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Malic_acid". A list of authors is available in Wikipedia. |